All Phenotypes Tg(Rorc-cre)1Litt MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Rorc-cre)1Litt
transgene insertion 1, Dan R Littman
MGI:3054098

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	MGI:7439998
cn2	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2⁺ Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	MGI:7439999
cn3	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311736
cn4	Bptf^em1Zfa/Bptf^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311743
cn5	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311735
cn6	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311734
cn7	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Rorc-cre)1Litt/0	Not Specified	MGI:4453324
cx8	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor^tm1(DTA)Riet Tg(Rorc-cre)1Litt/?	involves: 129P2/OlaHsd	MGI:3829422

Allelic Composition	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0
Genetic Background	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1^tm1.2Jae mutation (0 available); any Tet1 mutation (143 available)
Tet2^tm1.1Iaai mutation (2 available); any Tet2 mutation (779 available)
Tet3^tm1.1Yzhg mutation (0 available); any Tet3 mutation (60 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

hematopoietic system

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

immune system

enlarged spleen ( J:333574 )

• splenomegaly at age 5 weeks

enlarged lymph nodes ( J:333574 )

• lymphadenopathy at age 5 weeks

increased susceptibility to autoimmune disorder ( J:333574 )

Allelic Composition	Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2⁺ Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0
Genetic Background	involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased effector memory T-helper cell number ( J:333574 )

• greatly reduced CD4 expression upon T cell proliferation

immune system

immune system phenotype ( J:333574 )

N	• no autoimmune phenotypes • normal spleen and lymph node size • normal proportions of naive CD44- CD62L+ T lymphocyte compartments

decreased effector memory T-helper cell number ( J:333574 )

• greatly reduced CD4 expression upon T cell proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

abnormal interleukin secretion ( J:259392 )

• reduced IL22 secretion from intestinal lamina propria lymphocytes of C. rodentium exposed mice

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, increased mortality, reduced IL22-secreting cells in the intestine, and IL22 secretion from intestinal lamina propria compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, ILC1 and ILC2s numbers are normal

Allelic Composition	Bptf^em1Zfa/Bptf^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, and increased mortality compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to impaired proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, overexpression of Zfp292 rescues ILC3 proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• in C. rodentium exposed mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation

Allelic Composition	Ltbr^tm1Avt/Ltbr^tm1Avt Tg(Rorc-cre)1Litt/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbr^tm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

growth/size/body

weight loss ( J:158663 )

• exhibit weight loss post infection with C. rodentium

immune system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria

increased susceptibility to bacterial infection ( J:158663 )

• display weight loss, increased bacterial titers in the feces and blood and severe colon pathology after infection with Citrobacter rodentium

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )

• died at day 8-12 post-infection with C. rodentium

digestive/alimentary system

abnormal colon morphology ( J:158663 )

• display severe colon pathology post infection with C. rodentium

hematopoietic system

decreased neutrophil cell number ( J:158663 )

• reduced number of neutrophils in the colon lamina propria

homeostasis/metabolism

abnormal chemokine level ( J:158663 )

• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor^tm1(DTA)Riet Tg(Rorc-cre)1Litt/?
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

immune system

abnormal effector T cell morphology ( J:137020 )

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