Phenotypes associated with this allele

• Allele Symbol: Tg(WapMyc)212Bri
• Allele Name: transgene insertion 212, Ralph L Brinster
• Allele ID: MGI:3054251
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(WapMyc)212Bri/0 Tg(WapTgfa)215Bri/0	involves: C57BL/6 * SJL	MGI:3800662
tg2	Tg(WapMyc)212Bri/0	FVB.Cg-Tg(WapMyc)212Bri	MGI:3800659
tg3	Tg(WapMyc)212Bri/0	involves: C57BL/6 * SJL	MGI:3800802

Genotype
MGI:3800662

cx1

• Allelic Composition: Tg(WapMyc)212Bri/0; Tg(WapTgfa)215Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:56318 )

• female mice die at less than 4 months of age roughly 2 months after their first pregnancy

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:56318 )

♀ • involution is abolished and only a mild decrease in alveolar size is observed postparturition

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

mammary gland hyperplasia ( J:56318 )

♀ • mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes

abnormal lactation ( J:56318 )

♀ • female mice do not lactate

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

integument

abnormal involution of the mammary gland ( J:56318 )

♀ • involution is abolished and only a mild decrease in alveolar size is observed postparturition

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

mammary gland hyperplasia ( J:56318 )

♀ • mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes

abnormal lactation ( J:56318 )

♀ • female mice do not lactate

Genotype
MGI:3800659

tg2

• Allelic Composition: Tg(WapMyc)212Bri/0
• Genetic Background: FVB.Cg-Tg(WapMyc)212Bri

endocrine/exocrine glands

abnormal mammary gland morphology ( J:114568 )

♀ • apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

♀ • ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

♀ • lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

♀ • cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

♀ • unlike wild-type mice, proliferation rates remain high as mice age

♀ • mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

♀ • cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands

neoplasm

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

integument

abnormal mammary gland morphology ( J:114568 )

♀ • apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

♀ • ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

♀ • lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

♀ • cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

♀ • unlike wild-type mice, proliferation rates remain high as mice age

♀ • mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

♀ • cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands

Genotype
MGI:3800802

tg3

• Allelic Composition: Tg(WapMyc)212Bri/0
• Genetic Background: involves: C57BL/6 * SJL

mortality/aging

premature death ( J:56318 )

• female mice die by 8 months of age

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:56318 )

♀ • female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

♀ • female mice do not lactate

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

integument

mammary gland alveolar hyperplasia ( J:56318 )

♀ • female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

♀ • female mice do not lactate