About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(WapTgfa)215Bri
transgene insertion 215, Ralph L Brinster
MGI:3054253
Summary 8 genotypes


Genotype
MGI:4429451
cx1
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4+
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone
increased metastatic potential ( J:156750 )
• at 8-months of age an increased number of large lung metastases are seen

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone




Genotype
MGI:4429452
cx2
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone
increased metastatic potential ( J:156750 )
• a significantly earlier incidence of lung metastases
• at 8-months of age there are more small and large lung metastases

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:156750




Genotype
MGI:4429453
cx3
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 FVB.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased




Genotype
MGI:3800804
cx4
Allelic
Composition		 Muc1tm1Gend/Muc1tm1Gend
Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc1tm1Gend mutation (1 available); any Muc1 mutation (39 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:123146 )
N
• despite prevalence of lung foci in mice expressing Tg(WapTgfa)215Bri alone in a C57BL/6 background, no metastatic adenocarcinomas or lymphomas are observed in the lung
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
mammary gland hyperplasia ( J:123146 )
• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone

integument
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
mammary gland hyperplasia ( J:123146 )
• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone




Genotype
MGI:3800662
cx5
Allelic
Composition		 Tg(WapMyc)212Bri/0
Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapMyc)212Bri mutation (1 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:56318 )
• female mice die at less than 4 months of age roughly 2 months after their first pregnancy

endocrine/exocrine glands
abnormal involution of the mammary gland ( J:56318 )
• involution is abolished and only a mild decrease in alveolar size is observed postparturition
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
mammary gland hyperplasia ( J:56318 )
• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
abnormal lactation ( J:56318 )
• female mice do not lactate

neoplasm
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

integument
abnormal involution of the mammary gland ( J:56318 )
• involution is abolished and only a mild decrease in alveolar size is observed postparturition
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
mammary gland hyperplasia ( J:56318 )
• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
abnormal lactation ( J:56318 )
• female mice do not lactate




Genotype
MGI:3800805
tg6
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age
increased lymphoma incidence ( J:123146 )
• mice exhibit pulmonary foci that display perivascular lymphocytic infiltration and perivascular lymphomas of unknown origins as well as 1 metastatic adenocarcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age

integument
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age




Genotype
MGI:3800661
tg7
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 FVB.Cg-Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:114568 )
• apoptosis in the mammary gland are reduced prior to 12 weeks of age and increased after 16 weeks of age compared to in wild-type mice
mammary gland duct hyperplasia ( J:114568 )
• mice exhibit increased ductal cell proliferation with greater lobular development compared to in wild-type mice
abnormal mammary gland lobule morphology ( J:114568 )
• lobules contain more cells than in wild-type mice
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue
mammary gland hyperplasia ( J:114568 )
• cell proliferation in lobules of the mammary gland is 7-fold higher than in wild-type mice after 16 weeks of age
• unlike in wild-type mice, proliferation rates remain high as mice age
• mice exhibit increased number and size of hyperplastic areas compared to in wild-type mice
• cell proliferation of normal cells in tumor containing glands is increased compared to in non-tumor containing glands

neoplasm
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue

integument
abnormal mammary gland morphology ( J:114568 )
• apoptosis in the mammary gland are reduced prior to 12 weeks of age and increased after 16 weeks of age compared to in wild-type mice
mammary gland duct hyperplasia ( J:114568 )
• mice exhibit increased ductal cell proliferation with greater lobular development compared to in wild-type mice
abnormal mammary gland lobule morphology ( J:114568 )
• lobules contain more cells than in wild-type mice
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue
mammary gland hyperplasia ( J:114568 )
• cell proliferation in lobules of the mammary gland is 7-fold higher than in wild-type mice after 16 weeks of age
• unlike in wild-type mice, proliferation rates remain high as mice age
• mice exhibit increased number and size of hyperplastic areas compared to in wild-type mice
• cell proliferation of normal cells in tumor containing glands is increased compared to in non-tumor containing glands




Genotype
MGI:3800803
tg8
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:56318 )
• female mice die by 14 months of age

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas
mammary gland hyperplasia ( J:56318 )
• female mice exhibit precocious glandular development
• glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors
lactation failure ( J:56318 )
• female mice do not lactate

neoplasm
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas

reproductive system
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice

integument
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas
mammary gland hyperplasia ( J:56318 )
• female mice exhibit precocious glandular development
• glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors
lactation failure ( J:56318 )
• female mice do not lactate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory