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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(WapTgfa)215Bri
transgene insertion 215, Ralph L Brinster
MGI:3054253
Summary 8 genotypes


Genotype
MGI:4429451
cx1
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4+
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone
increased metastatic potential ( J:156750 )
• at 8-months of age an increased number of large lung metastases are seen

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone




Genotype
MGI:4429452
cx2
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone
increased metastatic potential ( J:156750 )
• a significantly earlier incidence of lung metastases
• at 8-months of age there are more small and large lung metastases

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:156750




Genotype
MGI:4429453
cx3
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 FVB.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased




Genotype
MGI:3800804
cx4
Allelic
Composition		 Muc1tm1Gend/Muc1tm1Gend
Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc1tm1Gend mutation (1 available); any Muc1 mutation (39 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:123146 )
N
• despite prevalence of lung foci in mice expressing Tg(WapTgfa)215Bri alone in a C57BL/6 background, no metastatic adenocarcinomas or lymphomas are observed in the lung
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
mammary gland hyperplasia ( J:123146 )
• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone

integument
increased mammary gland tumor incidence ( J:123146 )
• 37% mice develop mammary gland tumors within 1 year with mean onset at 52 weeks of age and earliest onset at 24 weeks of age
mammary gland hyperplasia ( J:123146 )
• mice exhibit fewer hyperplastic foci than in mice expressing Tg(WapTgfa)215Bri alone




Genotype
MGI:3800662
cx5
Allelic
Composition		 Tg(WapMyc)212Bri/0
Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapMyc)212Bri mutation (1 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:56318 )
• female mice die at less than 4 months of age roughly 2 months after their first pregnancy

endocrine/exocrine glands
abnormal involution of the mammary gland ( J:56318 )
• involution is abolished and only a mild decrease in alveolar size is observed postparturition
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
mammary gland hyperplasia ( J:56318 )
• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
abnormal lactation ( J:56318 )
• female mice do not lactate

neoplasm
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

integument
abnormal involution of the mammary gland ( J:56318 )
• involution is abolished and only a mild decrease in alveolar size is observed postparturition
increased mammary gland tumor incidence ( J:56318 )
• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender
• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology
• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing
mammary gland hyperplasia ( J:56318 )
• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes
abnormal lactation ( J:56318 )
• female mice do not lactate




Genotype
MGI:3800805
tg6
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age
increased lymphoma incidence ( J:123146 )
• mice exhibit pulmonary foci that display perivascular lymphocytic infiltration and perivascular lymphomas of unknown origins as well as 1 metastatic adenocarcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age

integument
increased mammary gland tumor incidence ( J:123146 )
• all mice develop mammary gland tumors within 1 year with mean onset at 6 months of age and earliest onset at 12 weeks of age




Genotype
MGI:3800661
tg7
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 FVB.Cg-Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:114568 )
• apoptosis in the mammary gland are reduced prior to 12 weeks of age and increased after 16 weeks of age compared to in wild-type mice
mammary gland duct hyperplasia ( J:114568 )
• mice exhibit increased ductal cell proliferation with greater lobular development compared to in wild-type mice
abnormal mammary gland lobule morphology ( J:114568 )
• lobules contain more cells than in wild-type mice
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue
mammary gland hyperplasia ( J:114568 )
• cell proliferation in lobules of the mammary gland is 7-fold higher than in wild-type mice after 16 weeks of age
• unlike in wild-type mice, proliferation rates remain high as mice age
• mice exhibit increased number and size of hyperplastic areas compared to in wild-type mice
• cell proliferation of normal cells in tumor containing glands is increased compared to in non-tumor containing glands

neoplasm
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue

integument
abnormal mammary gland morphology ( J:114568 )
• apoptosis in the mammary gland are reduced prior to 12 weeks of age and increased after 16 weeks of age compared to in wild-type mice
mammary gland duct hyperplasia ( J:114568 )
• mice exhibit increased ductal cell proliferation with greater lobular development compared to in wild-type mice
abnormal mammary gland lobule morphology ( J:114568 )
• lobules contain more cells than in wild-type mice
increased mammary gland tumor incidence ( J:114568 )
• tumors exhibit high cell proliferation rates similar to hyperpastic mammary gland tissue
mammary gland hyperplasia ( J:114568 )
• cell proliferation in lobules of the mammary gland is 7-fold higher than in wild-type mice after 16 weeks of age
• unlike in wild-type mice, proliferation rates remain high as mice age
• mice exhibit increased number and size of hyperplastic areas compared to in wild-type mice
• cell proliferation of normal cells in tumor containing glands is increased compared to in non-tumor containing glands




Genotype
MGI:3800803
tg8
Allelic
Composition		 Tg(WapTgfa)215Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:56318 )
• female mice die by 14 months of age

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas
mammary gland hyperplasia ( J:56318 )
• female mice exhibit precocious glandular development
• glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors
lactation failure ( J:56318 )
• female mice do not lactate

neoplasm
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas

reproductive system
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice

integument
abnormal mammary gland growth during pregnancy ( J:56318 )
• female mice produce precocious small alveoli by day 14 of pregnancy unlike in wild-type mice
increased mammary gland tumor incidence ( J:56318 )
• female mice develop mammary gland tumors and die by 14 months of age
• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland
• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci
• while lung metastasis is rare (in 1 of 40 mice), most tumors are transplantable
• however, virgin females do not develop mammary gland tumors
increased mammary adenocarcinoma incidence ( J:56318 )
• most tumors are well differentiated adenomas and adenocarcinomas
mammary gland hyperplasia ( J:56318 )
• female mice exhibit precocious glandular development
• glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors
lactation failure ( J:56318 )
• female mice do not lactate




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
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