Phenotypes associated with this allele

• Allele Symbol: Nav2^{Gt(OST125046)Lex}
• Allele Name: gene trap OST125046, Lexicon Genetics
• Allele ID: MGI:3054375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nav2^Gt(OST125046)Lex/Nav2^Gt(OST125046)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3054657

Genotype
MGI:3054657

hm1

• Allelic Composition: Nav2^{Gt(OST125046)Lex}/Nav2^{Gt(OST125046)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:92175 )

• mutants move around less in an open field and display less rearing and hole poking compared to wild-type mice

decreased startle reflex ( J:92175 )

• the acoustic startle threshold is increased to 90 dB compared to 80 dB in wild-type mice

increased thermal nociceptive threshold ( J:92175 )

• increased latencies were seen at 55^oC and 57.5^oC in a hot plate test

• body temperatures were not significantly different and no difference in latencies in a warm water tail withdrawal test were seen

growth/size/body

weight loss ( J:92175 )

• progressive weight loss is seen beginning before 4 weeks of age with an associated decrease in the weight of most organs except the thymus and gonads

taste/olfaction

abnormal olfaction ( J:92175 )

• mutants take a longer time, travel more distance, and fail more frequently in search of food hidden in sawdust

vision/eye

abnormal optic nerve morphology ( J:92175 )

• degeneration results in severe hypoplasia of the optic nerve and a visibly smaller optic disc

• oligodendrocyte placement around the optic nerve is disorganized

nervous system

abnormal optic nerve morphology ( J:92175 )

• degeneration results in severe hypoplasia of the optic nerve and a visibly smaller optic disc

• oligodendrocyte placement around the optic nerve is disorganized