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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nt5etm1Jgsc
targeted mutation 1, Jurgen Schnermann
MGI:3054787
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nt5etm1Jgsc/Nt5etm1Jgsc involves: 129S/SvEv * C57BL/6J MGI:3055092


Genotype
MGI:3055092
hm1
Allelic
Composition		 Nt5etm1Jgsc/Nt5etm1Jgsc
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5etm1Jgsc mutation (0 available); any Nt5e mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal renal vascular resistance ( J:92598 )
• homozygotes have a decreased ability to change glomerular arteriole tone in response to changes in luminal NaCl concentrations

homeostasis/metabolism
increased circulating alkaline phosphatase level ( J:92598 )
• increased serum alkaline phosphatase levels are seen however no other differences in plasma constituents (BUN, creatinine, Na, etc) are seen
abnormal response/metabolism to endogenous compounds ( J:92598 )
• the magnitude of bradycardia induced by treatment with 5'-AMP is decreased compared to wild-type mice

renal/urinary system
abnormal renal vascular resistance ( J:92598 )
• homozygotes have a decreased ability to change glomerular arteriole tone in response to changes in luminal NaCl concentrations




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory