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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F11rtm1.1Dej
targeted mutation 1.1, Elisabetta Dejana
MGI:3054821
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F11rtm1.1Dej/F11rtm1.1Dej Not Specified MGI:3054866
cn2
 		F11rtm1Dej/F11rtm1.1Dej
Tg(Tek-cre)1Ywa/0 		Not Specified MGI:3054867


Genotype
MGI:3054866
hm1
Allelic
Composition		 F11rtm1.1Dej/F11rtm1.1Dej
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11rtm1.1Dej mutation (0 available); any F11r mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:92592 )
• the migratory ability of the dendritic cells is increased
increased susceptibility to type IV hypersensitivity reaction ( J:92592 )
• exposure to oxazolone induces increased ear swelling in mutants compared to wild-type mice




Genotype
MGI:3054867
cn2
Allelic
Composition		 F11rtm1Dej/F11rtm1.1Dej
Tg(Tek-cre)1Ywa/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11rtm1.1Dej mutation (0 available); any F11r mutation (31 available)
F11rtm1Dej mutation (0 available); any F11r mutation (31 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:92592 )
N
• dendritic cell migratory ability is not different from control




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory