Phenotypes associated with this allele

• Allele Symbol: mix
• Allele Name: inner ear dysfuntion, Malou Hultcrantz
• Allele ID: MGI:3054823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	mix/mix^+	involves: C57BL/6J * NMRI	MGI:3054829

Genotype
MGI:3054829

ht1

• Allelic Composition: mix/mix⁺
• Genetic Background: involves: C57BL/6J * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:92589 )

• position change and acceleration reflexes are impaired

impaired righting response ( J:92589 )

• the air righting response is impaired

impaired swimming ( J:92589 )

head tossing ( J:92589 )

• before starting to circle head tossing is seen

circling ( J:92589 )

hearing/vestibular/ear

abnormal Reissner membrane morphology ( J:92589 )

• the Reissner membrane is displaced following the inferior and lateral boundaries of the scala media resulting in the absence of the endolymphatic space

absent cochlear outer hair cells ( J:92589 )

• no outer hair cells are seen

cochlear hair cell degeneration ( J:92589 )

• hair cells degenerate and are replaced with supporting cells

organ of Corti degeneration ( J:92589 )

stria vascularis degeneration ( J:92589 )

• the stria vascularis is completely degenerated

abnormal scala vestibuli morphology ( J:92589 )

• fewer nerve fibers are seen in the utricle

vestibular hair cell degeneration ( J:92589 )

• in the ampulla and utricle remnants of degenerated hair cells are seen along with increased numbers of supporting cells

absent endolymphatic sac ( J:92589 )

deafness ( J:92589 )

• mutants are deaf from birth

reproductive system

male infertility ( J:92589 )

♂

nervous system

absent cochlear outer hair cells ( J:92589 )

• no outer hair cells are seen

cochlear hair cell degeneration ( J:92589 )

• hair cells degenerate and are replaced with supporting cells

vestibular hair cell degeneration ( J:92589 )

• in the ampulla and utricle remnants of degenerated hair cells are seen along with increased numbers of supporting cells

cochlear ganglion hypoplasia ( J:92589 )

• the number of spiral ganglion cells is reduced