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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rxfp1tm1Aia
targeted mutation 1, Alexander I Agoulnik
MGI:3054831
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rxfp1tm1Aia/Rxfp1tm1Aia involves: 129S7/SvEvBrd * C57BL/6J MGI:3054969
cx2
 		Rxfp1tm1Aia/Rxfp1tm1Aia
Rxfp2tm1Aia/Rxfp2tm1Aia 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3054971
cx3
 		Rxfp1tm1Aia/Rxfp1tm1Aia
Tg(Ins2-Insl3)4Imad/0 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3054986


Genotype
MGI:3054969
hm1
Allelic
Composition		 Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal nipple development ( J:92627 )
• mutant females have underdeveloped nipples
decreased nipple size ( J:92627 )
• nipple size is significantly smaller than in wild-type females as seen on postpartum day 2
• although difference in nipple size is more striking during pregnancy and lactation, this effect is noted even in non-pregnant females
abnormal lactation ( J:92627 )
• all mutant females are unable to nurse their pups despite normal nursing behavior

reproductive system
abnormal parturition ( J:92627 )
• about 9% of mutant females are unable to deliver pups
• a greater percentage of pups are stillborn to mutant females compared to wild-type females regardless of the genotype of the pups

respiratory system
pulmonary fibrosis ( J:92627 )
• fibrosis is seen around the vascular bundles and the bronchioles but not in the parenchyma at 1 and 6 months of age

integument
abnormal nipple development ( J:92627 )
• mutant females have underdeveloped nipples
decreased nipple size ( J:92627 )
• nipple size is significantly smaller than in wild-type females as seen on postpartum day 2
• although difference in nipple size is more striking during pregnancy and lactation, this effect is noted even in non-pregnant females
abnormal lactation ( J:92627 )
• all mutant females are unable to nurse their pups despite normal nursing behavior




Genotype
MGI:3054971
cx2
Allelic
Composition		 Rxfp1tm1Aia/Rxfp1tm1Aia
Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Rxfp2tm1Aia mutation (0 available); any Rxfp2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased nipple size ( J:92627 )
• mutant females have small nipples
cryptorchism ( J:92627 )
• intra-abdominal cryptorchism is seen
• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

reproductive system
cryptorchism ( J:92627 )
• intra-abdominal cryptorchism is seen
• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion

respiratory system
respiratory system phenotype ( J:92627 )
N
• no significant fibrosis is seen in the lungs

integument
decreased nipple size ( J:92627 )
• mutant females have small nipples
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups




Genotype
MGI:3054986
cx3
Allelic
Composition		 Rxfp1tm1Aia/Rxfp1tm1Aia
Tg(Ins2-Insl3)4Imad/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Tg(Ins2-Insl3)4Imad mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased nipple size ( J:92627 )
• mutant females have small nipples
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

reproductive system
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes

integument
decreased nipple size ( J:92627 )
• mutant females have small nipples
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

skeleton
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes




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11/12/2024
MGI 6.24 		The Jackson Laboratory