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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-cre)#Zhu
transgene insertion, Yuan Zhuang
MGI:3054844
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cbx4tm1.1Gxu/Cbx4tm1.1Gxu
Tg(Lck-cre)#Zhu/0 		involves: 129S2/SvPas * C57BL/6 * SJL/J MGI:5489935
cn2
 		Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3774553
cn3
 		Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3774551
cn4
 		Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Tg(TcrAND)53Hed/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3774552
cn5
 		Mta2tm1Yzha/Mta2tm1Yzha
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3803012
cn6
 		Tcf12tm3Zhu/Tcf12tm3Zhu
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:3769725
cn7
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL MGI:5009806
cn8
 		Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J MGI:4358230
cn9
 		Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+
Igs12tm1Zhu/Igs12tm1Zhu
Ptprca/Ptprcb
Tg(Lck-cre)#Zhu/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J MGI:5557973
cn10
 		Adam10tm1Zhu/Adam10tm1Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL/J MGI:3809609
cn11
 		Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J MGI:5009805
cn12
 		Adam10tm1Zhu/Adam10tm1.1Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J MGI:3809608
cn13
 		Tcf12tm3Zhu/Tcf12tm3Zhu
Tg(Lck-cre)#Zhu/0 		involves: C57BL/6 * SJL/J MGI:3769726
cn14
 		Setd2tm1c(NCOM)Mfgc/Setd2tm1c(NCOM)Mfgc
Tg(Lck-cre)#Zhu/0 		involves: C57BL/6 * SJL/J MGI:6115875


Genotype
MGI:5489935
cn1
Allelic
Composition		 Cbx4tm1.1Gxu/Cbx4tm1.1Gxu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbx4tm1.1Gxu mutation (0 available); any Cbx4 mutation (16 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194053 )
N
• thymus numbers are similar to controls




Genotype
MGI:3774553
cn2
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

immune system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells




Genotype
MGI:3774551
cn3
Allelic
Composition		 Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:75746 )
N
• no developmental defects are observed in the B cell lineage in mice
• unexpectedly, mice show normal T cell development
• no reductions in total thymocytes or double-positive thymocytes, or increase in single-positive thymocytes is observed




Genotype
MGI:3774552
cn4
Allelic
Composition		 Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Lck-cre)#Zhu mutation (0 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:75746 )
N
• TCR mediated positive T cell selection is unaffected by Tcfe2a deletion in T cells, in contrast to mice with total Tcfe2a deficiency

neoplasm
neoplasm ( J:75746 )
N
• in contrast to totally Tcfe2a-deficient mice, T cell specific Tcfe2a-deficient mice do not develop thymic lymphomas between 4 and 16 months of age




Genotype
MGI:3803012
cn5
Allelic
Composition		 Mta2tm1Yzha/Mta2tm1Yzha
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mta2tm1Yzha mutation (0 available); any Mta2 mutation (38 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137101 )
N
• despite an increase in T cell proliferation, mice fail to exhibit other auto-immune phenotypes observed in Mta2tm1.1Yzha homozygotes
increased T cell proliferation ( J:137101 )
• upon stimulation

hematopoietic system
increased T cell proliferation ( J:137101 )
• upon stimulation

cellular
increased T cell proliferation ( J:137101 )
• upon stimulation




Genotype
MGI:3769725
cn6
Allelic
Composition		 Tcf12tm3Zhu/Tcf12tm3Zhu
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:129570 )
• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells
thymus hypoplasia ( J:129570 )
• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)
increased double-negative T cell number ( J:129570 )
• T cell differentiation is blocked at the double negative stage
• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice
• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity
decreased T cell number ( J:129570 )
• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice
decreased double-positive T cell number ( J:129570 )
• mice exhibit less than 1% of the double positive T cells found in wild-type mice

hematopoietic system
increased T cell proliferation ( J:129570 )
• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells
thymus hypoplasia ( J:129570 )
• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)
increased double-negative T cell number ( J:129570 )
• T cell differentiation is blocked at the double negative stage
• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice
• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity
decreased T cell number ( J:129570 )
• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice
decreased double-positive T cell number ( J:129570 )
• mice exhibit less than 1% of the double positive T cells found in wild-type mice

endocrine/exocrine glands
thymus hypoplasia ( J:129570 )
• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)

cellular
increased T cell proliferation ( J:129570 )
• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells




Genotype
MGI:5009806
cn7
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Id3tm2.1Zhu mutation (1 available); any Id3 mutation (16 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:172701 )
• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland

hematopoietic system
decreased T cell number ( J:172701 )
• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland




Genotype
MGI:4358230
cn8
Allelic
Composition		 Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4tm1.1Wtao mutation (0 available); any Stk4 mutation (74 available)
Stk4tm1.2Wtao mutation (0 available); any Stk4 mutation (74 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:152323 )
• peripheral T cells
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes

hematopoietic system
decreased T cell number ( J:152323 )
• peripheral T cells
decreased CD4-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes
decreased CD8-positive, alpha-beta T cell number ( J:152323 )
• in the blood, spleen, and lymph nodes

endocrine/exocrine glands




Genotype
MGI:5557973
cn9
Allelic
Composition		 Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+
Igs12tm1Zhu/Igs12tm1Zhu
Ptprca/Ptprcb
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu mutation (0 available); any Dhx9 mutation (76 available)
Igs12tm1Zhu mutation (0 available); any Igs12 mutation (0 available)
Ptprca mutation (51 available); any Ptprc mutation (189 available)
Ptprcb mutation (8 available); any Ptprc mutation (189 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:207361 )
• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells

hematopoietic system
abnormal T cell differentiation ( J:207361 )
• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells




Genotype
MGI:3809609
cn10
Allelic
Composition		 Adam10tm1Zhu/Adam10tm1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1Zhu mutation (1 available); any Adam10 mutation (38 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
abnormal T cell differentiation ( J:139042 )
• thymocyte development is impaired

hematopoietic system
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
abnormal T cell differentiation ( J:139042 )
• thymocyte development is impaired

endocrine/exocrine glands
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice




Genotype
MGI:5009805
cn11
Allelic
Composition		 Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3tm2.1Zhu mutation (1 available); any Id3 mutation (16 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
parotid gland inflammation ( J:172701 )
• between 8 and 12 months
submandibular gland inflammation ( J:172701 )
• between 8 and 12 months
abnormal T cell differentiation ( J:172701 )
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
decreased T cell number ( J:172701 )
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:172701 )
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
decreased CD8-positive, alpha-beta T cell number ( J:172701 )
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice

digestive/alimentary system
parotid gland inflammation ( J:172701 )
• between 8 and 12 months
submandibular gland inflammation ( J:172701 )
• between 8 and 12 months
decreased salivation ( J:172701 )
• after pilocarpine stimulation

endocrine/exocrine glands
parotid gland inflammation ( J:172701 )
• between 8 and 12 months
submandibular gland inflammation ( J:172701 )
• between 8 and 12 months
decreased salivation ( J:172701 )
• after pilocarpine stimulation

hematopoietic system
abnormal T cell differentiation ( J:172701 )
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
decreased T cell number ( J:172701 )
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:172701 )
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
decreased CD8-positive, alpha-beta T cell number ( J:172701 )
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice

homeostasis/metabolism
decreased salivation ( J:172701 )
• after pilocarpine stimulation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Sjogren's syndrome DOID:12894 OMIM:270150
 J:172701




Genotype
MGI:3809608
cn12
Allelic
Composition		 Adam10tm1Zhu/Adam10tm1.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Zhu mutation (0 available); any Adam10 mutation (38 available)
Adam10tm1Zhu mutation (1 available); any Adam10 mutation (38 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
abnormal T cell differentiation ( J:139042 )
• thymocyte development is impaired

hematopoietic system
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
abnormal T cell differentiation ( J:139042 )
• thymocyte development is impaired

endocrine/exocrine glands
thymus hypoplasia ( J:139042 )
• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice




Genotype
MGI:3769726
cn13
Allelic
Composition		 Tcf12tm3Zhu/Tcf12tm3Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:129570 )
• mice exhibit an accumulation of CD8+ single positive T cells

hematopoietic system
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:129570 )
• mice exhibit an accumulation of CD8+ single positive T cells

endocrine/exocrine glands
decreased thymocyte number ( J:129570 )
• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice




Genotype
MGI:6115875
cn14
Allelic
Composition		 Setd2tm1c(NCOM)Mfgc/Setd2tm1c(NCOM)Mfgc
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd2tm1c(NCOM)Mfgc mutation (1 available); any Setd2 mutation (102 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:243973 )
N
• alpha-beta T cell number
increased gamma-delta T cell number ( J:243973 )
• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)
• increase in percentage gamma-delta CD3e+ T cells in epithelium
• increase in gamma-delta to alpha-beta Peyers patch T cells ratio
• increase in percentage gamma-delta T cells in Peyers patch
• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio

immune system
increased gamma-delta T cell number ( J:243973 )
• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)
• increase in percentage gamma-delta CD3e+ T cells in epithelium
• increase in gamma-delta to alpha-beta Peyers patch T cells ratio
• increase in percentage gamma-delta T cells in Peyers patch
• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio

neoplasm
neoplasm ( J:243973 )
N
• no lymphoma development after 10 months of age




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Send questions and comments to User Support. 		last database update
11/12/2024
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