Analysis Tools
hematopoietic system
| N |
• thymus numbers are similar to controls
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Allele Symbol Allele Name Allele ID |
Tg(Lck-cre)#Zhu transgene insertion, Yuan Zhuang MGI:3054844 |
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| Summary |
14 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• thymus numbers are similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is a developmental block between the double negative and immature single positive stages of T cell development
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• 2-week old mice exhibit a dramatic accumulation of double negative T cells
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• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells
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• there is a developmental block between the double negative and immature single positive stages of T cell development
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• 2-week old mice exhibit a dramatic accumulation of double negative T cells
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• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no developmental defects are observed in the B cell lineage in mice
• unexpectedly, mice show normal T cell development
• no reductions in total thymocytes or double-positive thymocytes, or increase in single-positive thymocytes is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• TCR mediated positive T cell selection is unaffected by Tcfe2a deletion in T cells, in contrast to mice with total Tcfe2a deficiency
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| N |
• in contrast to totally Tcfe2a-deficient mice, T cell specific Tcfe2a-deficient mice do not develop thymic lymphomas between 4 and 16 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite an increase in T cell proliferation, mice fail to exhibit other auto-immune phenotypes observed in Mta2tm1.1Yzha homozygotes
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• upon stimulation
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• upon stimulation
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• upon stimulation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells
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• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)
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• T cell differentiation is blocked at the double negative stage
• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice
• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity
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• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice
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• mice exhibit less than 1% of the double positive T cells found in wild-type mice
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• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells
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• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)
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• T cell differentiation is blocked at the double negative stage
• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice
• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity
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• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice
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• mice exhibit less than 1% of the double positive T cells found in wild-type mice
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• thymus cellularity is decreased 20-fold (6.7+/-3.1x106 cells compared to 134.4+/-33.4x106 cells in wild-type thymus)
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• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)
• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice
• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland
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• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• peripheral T cells
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• in the blood, spleen, and lymph nodes
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• in the blood, spleen, and lymph nodes
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• in the thymus
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• peripheral T cells
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• in the blood, spleen, and lymph nodes
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• in the blood, spleen, and lymph nodes
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• in the thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells
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• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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• thymocyte development is impaired
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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• thymocyte development is impaired
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• between 8 and 12 months
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• between 8 and 12 months
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• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
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• slightly and unchanged by age
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• slightly and unchanged by age
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• in the thymus
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• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
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• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
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• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
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• between 8 and 12 months
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• between 8 and 12 months
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• after pilocarpine stimulation
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• between 8 and 12 months
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• between 8 and 12 months
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• after pilocarpine stimulation
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• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
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• slightly and unchanged by age
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• slightly and unchanged by age
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• in the thymus
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• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
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• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
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• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
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• after pilocarpine stimulation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Sjogren's syndrome | DOID:12894 |
OMIM:270150 |
J:172701 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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• thymocyte development is impaired
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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• thymocyte development is impaired
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• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
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• mice exhibit an accumulation of CD8+ single positive T cells
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• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
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• mice exhibit an accumulation of CD8+ single positive T cells
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• 39.3+/-15.4x106 compared to 133+/-32.6x106 in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• alpha-beta T cell number
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• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)
• increase in percentage gamma-delta CD3e+ T cells in epithelium
• increase in gamma-delta to alpha-beta Peyers patch T cells ratio
• increase in percentage gamma-delta T cells in Peyers patch
• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio
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• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)
• increase in percentage gamma-delta CD3e+ T cells in epithelium
• increase in gamma-delta to alpha-beta Peyers patch T cells ratio
• increase in percentage gamma-delta T cells in Peyers patch
• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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