All Phenotypes Rassf5<tm1Kina> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rassf5^tm1Kina/Rassf5^tm1Kina	B6.Cg-Rassf5^tm1Kina	MGI:4939894
hm2	Rassf5^tm1Kina/Rassf5^tm1Kina	involves: C57BL/6 * CBA * ICR	MGI:3054901
ht3	Rassf5^tm1Kina/Rassf5⁺	involves: C57BL/6 * CBA * ICR	MGI:3054902
cx4	Cdkn1b^tm2Kin/Cdkn1b^tm2Kin Rassf5^tm1Kina/Rassf5^tm1Kina	involves: C57BL/6 * CBA	MGI:4939905

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:168749 )

increased B cell number ( J:168749 )

• total B and T cells are increased by about 50%

increased plasma cell number ( J:168749 )

• CD138+B220+ plasma cells are increased in 10 month old female mutants

increased T cell number ( J:168749 )

• total B and T cells are increased by about 50%

increased memory T cell number ( J:168749 )

• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants

abnormal lymphocyte physiology ( J:168749 )

• lymphocyte hyperproliferation, with lymphocytes exhibiting enhanced S phase entry after stimulation

increased B cell proliferation ( J:168749 )

• primary B cells exhibit accelearated S phase entry after stimulation

increased T cell proliferation ( J:168749 )

• primary T cells exhibit accelerated S phase entry after stimulation

increased IgG level ( J:168749 )

• aged mice exhibit a 2-fold increase in serum IgG compared to wild-type mice

• deposits of IgG and C3 in the kidney

enlarged lymph nodes ( J:168749 )

increased anti-double stranded DNA antibody level ( J:168749 )

• aged mice exhibit high titers of antibodies to dsDNA

glomerulonephritis ( J:168749 )

• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months

neoplasm

increased hepatocellular carcinoma incidence ( J:168749 )

• mutants develop hepatocellular carcinomas after 1.5 years of age

increased B cell derived lymphoma incidence ( J:168749 )

• mutants develop B220+CD19+ diffuse large B cell lymphomas

• about 30% of mutants develop B cell lymphomas in peripheral lymph nodes and spleen at 1 year of age

• lymphomas are IgM+, IgD+, CD21+, CD23+, and mature B cell type; progressed lymphomas often lose these markers

• lymphomas are monoclonal or oligoclonal in origin

• B cell lymphomas are not related to severity of autoimmune phenotypes

increased lung adenocarcinoma incidence ( J:168749 )

• mutants develop lung adenocarcinomas after 1.5 years of age

hematopoietic system

enlarged spleen ( J:168749 )

increased B cell number ( J:168749 )

• total B and T cells are increased by about 50%

increased plasma cell number ( J:168749 )

• CD138+B220+ plasma cells are increased in 10 month old female mutants

increased T cell number ( J:168749 )

• total B and T cells are increased by about 50%

increased memory T cell number ( J:168749 )

• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants

abnormal lymphocyte physiology ( J:168749 )

• lymphocyte hyperproliferation, with lymphocytes exhibiting enhanced S phase entry after stimulation

increased B cell proliferation ( J:168749 )

• primary B cells exhibit accelearated S phase entry after stimulation

increased T cell proliferation ( J:168749 )

• primary T cells exhibit accelerated S phase entry after stimulation

increased IgG level ( J:168749 )

• aged mice exhibit a 2-fold increase in serum IgG compared to wild-type mice

• deposits of IgG and C3 in the kidney

homeostasis/metabolism

increased urine protein level ( J:168749 )

renal/urinary system

increased urine protein level ( J:168749 )

glomerulonephritis ( J:168749 )

• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months

liver/biliary system

increased hepatocellular carcinoma incidence ( J:168749 )

• mutants develop hepatocellular carcinomas after 1.5 years of age

cellular

increased B cell proliferation ( J:168749 )

• primary B cells exhibit accelearated S phase entry after stimulation

increased T cell proliferation ( J:168749 )

• primary T cells exhibit accelerated S phase entry after stimulation

growth/size/body

enlarged spleen ( J:168749 )

respiratory system

increased lung adenocarcinoma incidence ( J:168749 )

• mutants develop lung adenocarcinomas after 1.5 years of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:168749

Allelic Composition	Rassf5^tm1Kina/Rassf5^tm1Kina
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf5^tm1Kina mutation (0 available); any Rassf5 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal leukocyte migration ( J:92670 )

• defective chemokine-triggered lymphocyte adhesion and migration

abnormal thymus cell ratio ( J:92670 )

• decrease in double positive CD4+ CD8+ cells

• increase in single positive CD4+ and CD8+ cells

• cellular migration out of thymus is 10% of wildtype

abnormal thymus corticomedullary boundary morphology ( J:92670 )

• boundary of cortex and medulla ambiguous

abnormal thymus medulla morphology ( J:92670 )

• spotty appearance of medulla

decreased thymocyte number ( J:92670 )

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

abnormal B cell differentiation ( J:92670 )

• impairment of B cell maturation

• defective trafficking of B cells into spleen

• increased number of immature B cells in blood

abnormal spleen red pulp morphology ( J:92670 )

• reciprocal increase in T and B cells in splenic red pulp

spleen hypoplasia ( J:92670 )

immune system

abnormal leukocyte migration ( J:92670 )

• defective chemokine-triggered lymphocyte adhesion and migration

abnormal thymus cell ratio ( J:92670 )

• decrease in double positive CD4+ CD8+ cells

• increase in single positive CD4+ and CD8+ cells

• cellular migration out of thymus is 10% of wildtype

abnormal thymus corticomedullary boundary morphology ( J:92670 )

• boundary of cortex and medulla ambiguous

abnormal thymus medulla morphology ( J:92670 )

• spotty appearance of medulla

decreased thymocyte number ( J:92670 )

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

abnormal B cell differentiation ( J:92670 )

• impairment of B cell maturation

• defective trafficking of B cells into spleen

• increased number of immature B cells in blood

abnormal spleen red pulp morphology ( J:92670 )

• reciprocal increase in T and B cells in splenic red pulp

spleen hypoplasia ( J:92670 )

abnormal lymph node cell ratio ( J:92670 )

• total lymphocyte numbers in peripheral lymph nodes are decreased to one half of wild-type

abnormal lymph node cortex morphology ( J:92670 )

• decrease in size and cellular density of B cell follicles and T cell zones

abnormal dendritic cell physiology ( J:92670 )

• reduced numbers of CD11c+ (Itgax) dendritic cells in spleen

• following activation, dermal and splenic dendritic cells fail to migrate to draining lymph nodes and white pulp

cellular

abnormal leukocyte migration ( J:92670 )

• defective chemokine-triggered lymphocyte adhesion and migration

endocrine/exocrine glands

abnormal thymus cell ratio ( J:92670 )

• decrease in double positive CD4+ CD8+ cells

• increase in single positive CD4+ and CD8+ cells

• cellular migration out of thymus is 10% of wildtype

abnormal thymus corticomedullary boundary morphology ( J:92670 )

• boundary of cortex and medulla ambiguous

abnormal thymus medulla morphology ( J:92670 )

• spotty appearance of medulla

decreased thymocyte number ( J:92670 )

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

Allelic Composition	Rassf5^tm1Kina/Rassf5⁺
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf5^tm1Kina mutation (0 available); any Rassf5 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymphoid hypoplasia ( J:92670 )

• total lymphocyte numbers in peripheral lymph nodes are decreased to one third of wild-type

Allelic Composition	Cdkn1b^tm2Kin/Cdkn1b^tm2Kin Rassf5^tm1Kina/Rassf5^tm1Kina
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm2Kin mutation (1 available); any Cdkn1b mutation (26 available)
Rassf5^tm1Kina mutation (0 available); any Rassf5 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:168749 )

• development of glomerulonephritis that is observed in single Rassf5 homozygotes is suppressed, in addition, CD138+B220+ plasma cells are reduced by 67%, CD44+CD62L- effector-memory T cells are reduced by 28%, and titers of antibodies to dsDNA are decreased by 58% compared to single Rassf5 homozygotes and deposition of IgG in the kidney is rarely detected compared to single Rassf5 homozygotes

homeostasis/metabolism

increased urine protein level ( J:168749 )

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

renal/urinary system

increased urine protein level ( J:168749 )

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

neoplasm

neoplasm ( J:168749 )

N	• mutants do not develop B cell lymphomas or other tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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