All Phenotypes Tnfrsf13c<tm1Mass> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf13c^tm1Mass
targeted mutation 1, Marc Schmidt-Supprian
MGI:3054891

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	C57BL/6-Tnfrsf13c^tm1Mass	MGI:3055132
hm2	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: C57BL/6	MGI:3809752
cn3	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6	MGI:3687509
cn4	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm5(Map3k14)Rsky}/Gt(ROSA)26Sor^{tm5(Map3k14)Rsky} Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6	MGI:3809750
cn5	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm6(Map3k14)Rsky}/Gt(ROSA)26Sor^{tm6(Map3k14)Rsky} Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6	MGI:3809751
cn6	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6 * NZB	MGI:5013718
cx7	Tg(Tnfsf13b)1Fma/? Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	B6.Cg-Tnfrsf13c^tm1Mass Tg(Tnfsf13b)1Fma	MGI:3841115
cx8	Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6	MGI:5013719
cx9	Igh^tm1.2Rsky/Igh⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: BALB/c * C57BL/6	MGI:3760856
cx10	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf2^tm1Rbr/Traf2^tm1Rbr	involves: C57BL/6	MGI:5013720
cx11	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf3^tm1Rbr/Traf3^tm1Rbr	involves: C57BL/6	MGI:5013721
cx12	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Tg(BCL2)22Wehi/0	involves: C57BL/6 * SJL	MGI:3687507

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	C57BL/6-Tnfrsf13c^tm1Mass

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:92732 )

• a block in B cell development from IgM⁺ (T1 + T2) to IgM^low (T3) cells is seen

decreased mature B cell number ( J:92732 )

• the number of mature recirculating B cells is reduced with about a 10-fold reduction in IgD⁺ B cells in the bone marrow and a 20-fold decrease in IgM^lowIgD⁺ B cells in the lymph nodes

decreased B-2 B cell number ( J:92732 )

• a reduction in peritoneal B2 cells but not B1 cells is seen

absent marginal zone B cells ( J:92732 )

abnormal B cell physiology ( J:113556 )

• there is about a third reduction in the number of B cells that survive 36 hours of in vitro culturing compared to controls

• addition of Tnfsf13b (BAFF) to the culture does not elevate survival

decreased IgG level ( J:92732 )

• the titers of IgG1, IgG2a, IgG2b, and IgG3 are reduced

decreased IgG1 level ( J:92732 )

• immunization with NP-CG produces a significantly smaller increase in IgG1 titers in mutants compared to wild-type mice and no secondary NP-specific response is detected in mutants

decreased IgG2a level ( J:92732 )

decreased IgG2b level ( J:92732 )

decreased IgG3 level ( J:92732 )

• immunization with NP-Ficoll produces a smaller increase in IgG3 titers in mutants compared to wild-type mice

decreased IgM level ( J:92732 )

• the titer of IgM but not IgA is reduced compared to wild-type mice

• immunization with NP-Ficoll produces a smaller increase in IgM titers in mutants compared to wild-type mice

immune system

arrested B cell differentiation ( J:92732 )

• a block in B cell development from IgM⁺ (T1 + T2) to IgM^low (T3) cells is seen

decreased mature B cell number ( J:92732 )

• the number of mature recirculating B cells is reduced with about a 10-fold reduction in IgD⁺ B cells in the bone marrow and a 20-fold decrease in IgM^lowIgD⁺ B cells in the lymph nodes

decreased B-2 B cell number ( J:92732 )

• a reduction in peritoneal B2 cells but not B1 cells is seen

absent marginal zone B cells ( J:92732 )

abnormal B cell physiology ( J:113556 )

• there is about a third reduction in the number of B cells that survive 36 hours of in vitro culturing compared to controls

• addition of Tnfsf13b (BAFF) to the culture does not elevate survival

decreased IgG level ( J:92732 )

• the titers of IgG1, IgG2a, IgG2b, and IgG3 are reduced

decreased IgG1 level ( J:92732 )

• immunization with NP-CG produces a significantly smaller increase in IgG1 titers in mutants compared to wild-type mice and no secondary NP-specific response is detected in mutants

decreased IgG2a level ( J:92732 )

decreased IgG2b level ( J:92732 )

decreased IgG3 level ( J:92732 )

• immunization with NP-Ficoll produces a smaller increase in IgG3 titers in mutants compared to wild-type mice

decreased IgM level ( J:92732 )

• the titer of IgM but not IgA is reduced compared to wild-type mice

• immunization with NP-Ficoll produces a smaller increase in IgM titers in mutants compared to wild-type mice

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased lymphocyte cell number ( J:139293 )

decreased mature B cell number ( J:139293 )

hematopoietic system

decreased lymphocyte cell number ( J:139293 )

decreased mature B cell number ( J:139293 )

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:113365 )

N	• normal numbers of mature B cells including follicular and marginal zone B cells are produced • spleens contain well-organized lymphoid architecture with normal follicles and distinct marginal zone

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm5(Map3k14)Rsky}/Gt(ROSA)26Sor^{tm5(Map3k14)Rsky} Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm5(Map3k14)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased lymphocyte cell number ( J:139293 )

decreased mature B cell number ( J:139293 )

hematopoietic system

decreased lymphocyte cell number ( J:139293 )

decreased mature B cell number ( J:139293 )

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm6(Map3k14)Rsky}/Gt(ROSA)26Sor^{tm6(Map3k14)Rsky} Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm6(Map3k14*)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased lymphocyte cell number ( J:139293 )

increased mature B cell number ( J:139293 )

hematopoietic system

increased lymphocyte cell number ( J:139293 )

increased mature B cell number ( J:139293 )

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

Allelic Composition	Tg(Tnfsf13b)1Fma/? Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	B6.Cg-Tnfrsf13c^tm1Mass Tg(Tnfsf13b)1Fma

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnfsf13b)1Fma mutation (0 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by BAFF incubation is defective in these mice

immune system

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by BAFF incubation is defective in these mice

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:172843 )

• in the spleen and lymph node

immune system

abnormal B cell differentiation ( J:172843 )

• in the spleen and lymph node

Allelic Composition	Igh^tm1.2Rsky/Igh⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:125719 )

• four fold reduction of mature B cells in the spleen

hematopoietic system

decreased mature B cell number ( J:125719 )

• four fold reduction of mature B cells in the spleen

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

hematopoietic system

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf3^tm1Rbr/Traf3^tm1Rbr
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
Traf3^tm1Rbr mutation (0 available); any Traf3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (2 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:113365 )

immune system

immune system phenotype ( J:92732 )

N	• B cell development is normal in these mutants unlike Tnfrsf13c^tm1Mass homozygotes

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