Phenotypes associated with this allele

• Allele Symbol: Tcirg1^tm1Utku
• Allele Name: targeted mutation 1, Nalan Utku
• Allele ID: MGI:3054898
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcirg1^tm1Utku/Tcirg1^tm1Utku	involves: 129X1/SvJ * C57BL/6	MGI:3055162

Genotype
MGI:3055162

hm1

• Allelic Composition: Tcirg1^tm1Utku/Tcirg1^tm1Utku
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:92730 )

• only attain about 30% of normal body weight

postnatal growth retardation ( J:92730 )

• "pronounced head size" at birth and retarded postnatal growth

hematopoietic system

thymus atrophy ( J:92730 )

• atrophic

increased granulocyte number ( J:92730 )

decreased lymphocyte cell number ( J:92730 )

decreased B cell number ( J:92730 )

• splenic B cells reduced by about 60%

decreased T cell number ( J:92730 )

• splenic T cells reduced by about 50%

abnormal spleen morphology ( J:92730 )

abnormal spleen red pulp morphology ( J:92730 )

• hyperplastic

• plasma cell hyperplasia

• increased granulopoiesis

• increased megakaryocytopoiesis

abnormal spleen white pulp morphology ( J:92730 )

• hypoplasia of splenic white pulp

decreased spleen B cell follicle size ( J:92730 )

• small B lymphocyte follicles

abnormal spleen B cell corona morphology ( J:92730 )

• disorganized

increased spleen germinal center number ( J:92730 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:92730 )

• large and disorganized

increased immunoglobulin level ( J:92730 )

increased IgG1 level ( J:92730 )

increased IgG2a level ( J:92730 )

increased IgM level ( J:92730 )

immune system

thymus atrophy ( J:92730 )

• atrophic

increased granulocyte number ( J:92730 )

decreased lymphocyte cell number ( J:92730 )

decreased B cell number ( J:92730 )

• splenic B cells reduced by about 60%

decreased T cell number ( J:92730 )

• splenic T cells reduced by about 50%

abnormal spleen morphology ( J:92730 )

abnormal spleen red pulp morphology ( J:92730 )

• hyperplastic

• plasma cell hyperplasia

• increased granulopoiesis

• increased megakaryocytopoiesis

abnormal spleen white pulp morphology ( J:92730 )

• hypoplasia of splenic white pulp

decreased spleen B cell follicle size ( J:92730 )

• small B lymphocyte follicles

abnormal spleen B cell corona morphology ( J:92730 )

• disorganized

increased spleen germinal center number ( J:92730 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:92730 )

• large and disorganized

abnormal Peyer's patch morphology ( J:92730 )

• lacking in cells

abnormal mesenteric lymph node morphology ( J:92730 )

• lacking in cells

abnormal peripheral lymph node morphology ( J:92730 )

• peripheral lymph nodes lacking in cells

• increased apoptosis of lymphoblasts and lymphocytes

abnormal immune system physiology ( J:92730 )

abnormal immune serum protein physiology ( J:92730 )

• hyperresponsiveness to antigens

increased immunoglobulin level ( J:92730 )

increased IgG1 level ( J:92730 )

increased IgG2a level ( J:92730 )

increased IgM level ( J:92730 )

endocrine/exocrine glands

thymus atrophy ( J:92730 )

• atrophic