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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TcraTcrb)1100Mjb
transgene insertion 1100, Michael J Bevan
MGI:3054907
Summary 44 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6 MGI:5805812
cn2
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6 * DBA/2 MGI:3590221
cn3
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Tg(TcraTcrb)1100Mjb/0
Albtm1(cre/ERT2)Mtz/Alb+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5056505
cn4
Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * DBA/2 MGI:5702406
cn5
Pgdtm1.1Pse/Pgdtm1.1Pse
Tg(Cd4-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * DBA/2 MGI:6751655
cx6
Cd226tm1.1Cln/Cd226tm1.1Cln
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb MGI:4454328
cx7
Havcr2tm1Vlcg/Havcr2tm1Vlcg
Tg(TcraTcrb)1100Mjb/?
B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb MGI:5703655
cx8
Id2tm1Ago/Id2tm1Ago
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Id2tm1Ago Tg(TcraTcrb)1100Mjb MGI:3806453
cx9
Tespa1tm1Smoc/Tespa1tm1Smoc
Tg(TcraTcrb)1100Mjb/0
B6.Cg-Tespa1tm1Smoc Tg(TcraTcrb)1100Mjb MGI:5432917
cx10
Itktm1Ljb/Itktm1Ljb
Tg(TcraTcrb)1100Mjb/?
involves: 129 * C57BL/6 * C57BL/10 MGI:4354589
cx11
Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/?
involves: 129P2/OlaHsd * C57BL/6 MGI:3622434
cx12
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)1100Mjb/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4454321
cx13
Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/?
involves: 129S4/SvJae * C57BL/6 MGI:3783835
cx14
Tagln2tm1Cdj/Tagln2tm1Cdj
Tg(TcraTcrb)1100Mjb/0
involves: 129S4/SvJae * C57BL/6 MGI:6119493
cx15
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
involves: 129S6/SvEvTac MGI:3714650
cx16
Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6 MGI:5438970
cx17
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
involves: 129S6/SvEvTac * C57BL/6 MGI:3714649
cx18
Tg(TcraTcrb)1100Mjb/?
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 MGI:4353114
cx19
Sh2d1atm1Pls/Sh2d1atm1Pls
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J MGI:5438969
cx20
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
involves: 129S/SvEv * C57BL/6 * Swiss Webster MGI:5811096
cx21
Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0
involves: 129/Sv * C57BL/6 MGI:4415311
cx22
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(TcraTcrb)1100Mjb/0
involves: 129/Sv * C57BL/6 MGI:3687241
cx23
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss MGI:3783840
cx24
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6 MGI:3783839
cx25
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)1100Mjb/0
involves: C3H * C57BL/6 MGI:3698307
cx26
Btlatm1Dgra/Btlatm1Dgra
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 MGI:3842633
cx27
Rr381em2Kap/Rr381em2Kap
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:7439198
cx28
H2-Kbm1/H2-Kbm1
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 MGI:3783777
cx29
H2-Kbm5/H2-Kbm5
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 MGI:3783851
cx30
Cd3etm1.1Geno/Cd3etm1.1Geno
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:5474202
cx31
Cd274tm1Shr/Cd274tm1Shr
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:4397688
cx32
Pdcd1tm1.1Shr/Pdcd1tm1.1Shr
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:4397687
cx33
Mapk1tm1Hed/Mapk1tm1Hed
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:3687240
cx34
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 MGI:4358198
cx35
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * C57BL/10Sg * C57BR/c MGI:3783836
cx36
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * C57BL/6J MGI:5438968
cx37
Tg(Ins2-OVA)307Wehi/0
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * C57BL/6JWehi MGI:3583243
cx38
Myo1gtm1.2Mfk/Myo1gtm1.2Mfk
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * FVB/N * SJL MGI:5581501
cx39
Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6J MGI:7580561
cx40
Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * MRL/Mp MGI:5292731
cx41
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 * Swiss Webster MGI:5811097
tg42
Tg(TcraTcrb)1100Mjb/? either: C57BL/6 or (involves: C57BL/6 * SJL) MGI:5292730
tg43
Tg(TcraTcrb)1100Mjb/? involves: C57BL/6 MGI:3783776
tg44
Tg(TcraTcrb)1100Mjb/? involves: C57BL/6 * MRL/Mp MGI:5292729


Genotype
MGI:5805812
cn1
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (62 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
• reduced CD4+CD8int intermediate cells

hematopoietic system
• reduced CD4+CD8int intermediate cells




Genotype
MGI:3590221
cn2
Allelic
Composition
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camltm1Rjb mutation (0 available); any Caml mutation (25 available)
Camltm2Rjb mutation (0 available); any Caml mutation (25 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced numbers of total thymocytes
• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

immune system
• reduced numbers of total thymocytes
• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

endocrine/exocrine glands
• reduced numbers of total thymocytes




Genotype
MGI:5056505
cn3
Allelic
Composition
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+
Tg(TcraTcrb)1100Mjb/0
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (97 available)
Gt(ROSA)26Sortm2(OVA/EGFP)Dwir mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• tamoxifen-treated mice exhibit increased serum alanine transaminase levels compared with un-induced mice
• however, un-induced mice exhibit normal alanine transaminase levels




Genotype
MGI:5702406
cn4
Allelic
Composition
Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acacatm1Dejs mutation (0 available); any Acaca mutation (128 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced

hematopoietic system
• cell survival is reduced
• significant CD8+ T cell expansion after Listeria-OVA exposure

cellular
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced




Genotype
MGI:6751655
cn5
Allelic
Composition
Pgdtm1.1Pse/Pgdtm1.1Pse
Tg(Cd4-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgdtm1.1Pse mutation (0 available); any Pgd mutation (21 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice

hematopoietic system
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice
• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function




Genotype
MGI:4454328
cx6
Allelic
Composition
Cd226tm1.1Cln/Cd226tm1.1Cln
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd226tm1.1Cln mutation (0 available); any Cd226 mutation (34 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• CD8 T cells kill B16 cells pulsed with OVA peptide 257-264 less effectively than control CD8 T cells
• CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with Pvr and pulsed with OVA peptide 257-264 fail to become activated
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type

immune system
• CD8 T cells kill B16 cells pulsed with OVA peptide 257-264 less effectively than control CD8 T cells
• CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with Pvr and pulsed with OVA peptide 257-264 fail to become activated
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type
• fewer IFN gamma secreting T cells are evident in lymph nodes after restimulation with the T cell lymphoma cell line EL-4 cells transfected with Pvr and pulsed with OVA peptide 257-264
• however, the frequency of IFN gamma secreting cells is similar to wild-type after restimulation with dendritic cells

cellular
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type




Genotype
MGI:5703655
cx7
Allelic
Composition
Havcr2tm1Vlcg/Havcr2tm1Vlcg
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Havcr2tm1Vlcg mutation (0 available); any Havcr2 mutation (35 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced persistence of CD8alphaloCD11ahi cells
• IFN-gamma producing cells are reduced at 7 days after infection and pulse with OVA

hematopoietic system
• reduced persistence of CD8alphaloCD11ahi cells




Genotype
MGI:3806453
cx8
Allelic
Composition
Id2tm1Ago/Id2tm1Ago
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
B6.Cg-Id2tm1Ago Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Ago mutation (0 available); any Id2 mutation (21 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• adoptive transfer studies indicate that there is impaired accumulation of effector CD8+ T cells possibly because of an increase in apoptosis in these cells with surviving cells developing a central memory-like phenotype

hematopoietic system
• adoptive transfer studies indicate that there is impaired accumulation of effector CD8+ T cells possibly because of an increase in apoptosis in these cells with surviving cells developing a central memory-like phenotype




Genotype
MGI:5432917
cx9
Allelic
Composition
Tespa1tm1Smoc/Tespa1tm1Smoc
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
B6.Cg-Tespa1tm1Smoc Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the thymus
• in the periphery

hematopoietic system
• in the thymus
• in the periphery




Genotype
MGI:4354589
cx10
Allelic
Composition
Itktm1Ljb/Itktm1Ljb
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Ljb mutation (0 available); any Itk mutation (50 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the altered CD8+ T cell development that generates a large proportion of memory T cells in Itktm1Ljb homozygotes does not occur in these mice




Genotype
MGI:3622434
cx11
Allelic
Composition
Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell

hematopoietic system
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell




Genotype
MGI:4454321
cx12
Allelic
Composition
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population

immune system
• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population




Genotype
MGI:3783835
cx13
Allelic
Composition
Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen
• many of the CD4 T cells express the transgenic TCR alpha chain
• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen

hematopoietic system
• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen
• many of the CD4 T cells express the transgenic TCR alpha chain
• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen




Genotype
MGI:6119493
cx14
Allelic
Composition
Tagln2tm1Cdj/Tagln2tm1Cdj
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln2tm1Cdj mutation (0 available); any Tagln2 mutation (21 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

hematopoietic system
• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation




Genotype
MGI:3714650
cx15
Allelic
Composition
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbptm1Luc mutation (1 available); any Tapbp mutation (24 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice show normal T cell development, including normal positive selection




Genotype
MGI:5438970
cx16
Allelic
Composition
Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Pls mutation (4 available); any Sh2d1a mutation (11 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• impaired adhesion to wild-type B cells when stimulated with ovalbumin
• however, T cells exhibit increased adhesion to and normal killing of B cells lacking Slamf6 (Sh2d1atm1Pls)
• in cytotoxic T cells stimulated with ovalbumin

hematopoietic system
• impaired adhesion to wild-type B cells when stimulated with ovalbumin
• however, T cells exhibit increased adhesion to and normal killing of B cells lacking Slamf6 (Sh2d1atm1Pls)




Genotype
MGI:3714649
cx17
Allelic
Composition
Tapbptm1Luc/Tapbptm1Luc
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbptm1Luc mutation (1 available); any Tapbp mutation (24 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection
• also observed to be defective
• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus
• male mutants also show skewing toward CD4+ lineage
• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls

immune system
N
• male mutants have normal-sized thymuses, whereas Tapbp-sufficient, transgenic males have a small thymus
• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection
• also observed to be defective
• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus
• male mutants also show skewing toward CD4+ lineage
• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls




Genotype
MGI:4353114
cx18
Allelic
Composition
Tg(TcraTcrb)1100Mjb/?
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
Themistm1Gasc mutation (1 available); any Themis mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes fail to exit the CD4hiCD8int stage to the CD8 single-positive stage
• the proportion and number of double-positive thymocytes is greater than controls
• very few single-positive thymocytes are generated in the thymus

hematopoietic system
• thymocytes fail to exit the CD4hiCD8int stage to the CD8 single-positive stage
• the proportion and number of double-positive thymocytes is greater than controls
• very few single-positive thymocytes are generated in the thymus




Genotype
MGI:5438969
cx19
Allelic
Composition
Sh2d1atm1Pls/Sh2d1atm1Pls
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Pls mutation (4 available); any Sh2d1a mutation (11 available)
Slamf6tm1Pls mutation (1 available); any Slamf6 mutation (33 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cells exhibit normal adhesion to wild-type B cells and B cells lacking Slamf6 (Sh2d1atm1Pls)




Genotype
MGI:5811096
cx20
Allelic
Composition
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(Cd4-NPM/ALK)N1Ingh mutation (0 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice do not develop lymphoid tumors, but present after a long latency with gastrointestinal stromal tumors
• mice present after a long latency with hepatocellular carcinomas and sarcomas
• mice present after a long latency with hepatocellular carcinomas and sarcomas

digestive/alimentary system
• mice do not develop lymphoid tumors, but present after a long latency with gastrointestinal stromal tumors

liver/biliary system
• mice present after a long latency with hepatocellular carcinomas and sarcomas




Genotype
MGI:4415311
cx21
Allelic
Composition
Xcl1tm1Rakr/Xcl1tm1Rakr
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
Xcl1tm1Rakr mutation (0 available); any Xcl1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
• 12 days after immunization in adoptive transfer experiments
• immunized T cells produce less IFN-gamma on day 12 compared with similarly treated wild-type cells

hematopoietic system
• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells
• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice
• 12 days after immunization in adoptive transfer experiments




Genotype
MGI:3687241
cx22
Allelic
Composition
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

hematopoietic system
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

endocrine/exocrine glands
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency




Genotype
MGI:3783840
cx23
Allelic
Composition
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (29 available); any H2 mutation (281 available)
H2s mutation (4 available); any H2 mutation (281 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3783839
cx24
Allelic
Composition
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (29 available); any H2 mutation (281 available)
H2d mutation (23 available); any H2 mutation (281 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3698307
cx25
Allelic
Composition
Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1Dbs mutation (0 available); any Lck mutation (95 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• transgenic CD8+ thymocytes are not fully mature
• positive selection of CD4 and CD8 lineage is diminished

immune system
• transgenic CD8+ thymocytes are not fully mature
• positive selection of CD4 and CD8 lineage is diminished

cellular
• transgenic CD8+ thymocytes are not fully mature




Genotype
MGI:3842633
cx26
Allelic
Composition
Btlatm1Dgra/Btlatm1Dgra
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Dgra mutation (1 available); any Btla mutation (30 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ T cells from these mutant mice induce diabetes as early as 6 days after transfer into Tg(Ins2-TFRC/OVA)296Wehi transgenic mice that express OVA in insulin-producing cells
• 60% of transgenic mice develop diabetes and almost all mice have invasive insulitis compared to transgenic mice receiving wild-type OT-I cells where 60% of mice display no disease
• mutant OT-I T cells found in the pancreatic lymph nodes have twice as much proliferation as controls 50 hours after transfer compared to transferred wild-type OT-I T cells
• two weeks after transfer, there are twice as many mutant OT-I T cells in pancreatic lymph nodes compared to wild-type OT-I T cells controls
• thus, mutant autoreactive OT-I CD8+ T cells are resistant to tolerance induction mechanisms that limit the expansion of autoreactive CD8 + T cells




Genotype
MGI:7439198
cx27
Allelic
Composition
Rr381em2Kap/Rr381em2Kap
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr381em2Kap mutation (0 available); any Rr381 mutation (0 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal MHC class-specific T cell development




Genotype
MGI:3783777
cx28
Allelic
Composition
H2-Kbm1/H2-Kbm1
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Kbm1 mutation (10 available); any H2-K mutation (31 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the transgenic TCR does not have a high affinity for the H2-Kbm1 allele leading to poor selection of T cell precursors for the CD8 single positive subset

hematopoietic system
• the transgenic TCR does not have a high affinity for the H2-Kbm1 allele leading to poor selection of T cell precursors for the CD8 single positive subset




Genotype
MGI:3783851
cx29
Allelic
Composition
H2-Kbm5/H2-Kbm5
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Kbm5 mutation (0 available); any H2-K mutation (31 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the transgenic TCR is positively selected for on this genetic background based on the high expression of TCR on peripheral CD8 T cells

hematopoietic system
• the transgenic TCR is positively selected for on this genetic background based on the high expression of TCR on peripheral CD8 T cells




Genotype
MGI:5474202
cx30
Allelic
Composition
Cd3etm1.1Geno/Cd3etm1.1Geno
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1.1Geno mutation (0 available); any Cd3e mutation (54 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive
• thymocytes accumulate at the DP3 stage
• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint
• thymocytes accumulate at the DP3 stage
• partial arrest at the DN3 stage
• expression analysis indicates a defect in positive selection
• strong decrease in the population of DP cells expressing high levels of CD4 and CD8
• decrease in the absolute number of thymocytes

hematopoietic system
• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive
• thymocytes accumulate at the DP3 stage
• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint
• thymocytes accumulate at the DP3 stage
• partial arrest at the DN3 stage
• expression analysis indicates a defect in positive selection
• decrease in the absolute number of thymocytes
• strong decrease in the population of DP cells expressing high levels of CD4 and CD8

endocrine/exocrine glands
• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive
• thymocytes accumulate at the DP3 stage




Genotype
MGI:4397688
cx31
Allelic
Composition
Cd274tm1Shr/Cd274tm1Shr
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1Shr mutation (2 available); any Cd274 mutation (70 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following adoptive transfer, T cells induce rapid onset of diabetes in RIP-ovahigh recipients within 1 to 3 weeks unlike similarly treated wild-type cells




Genotype
MGI:4397687
cx32
Allelic
Composition
Pdcd1tm1.1Shr/Pdcd1tm1.1Shr
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1.1Shr mutation (4 available); any Pdcd1 mutation (97 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ovalow recipients unlike similarly treated wild-type cells
• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ovahigh recipients unlike similarly treated wild-type cells
• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ovahigh recipients unlike similarly treated wild-type cells
• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ovahigh recipients unlike similarly treated wild-type cells
• following adoptive transfer, CD8+ T cells fail to undergo cross-tolerization when transplanted into RIP-ovahigh recipients unlike similarly treated wild-type cells
• following adoptive transfer, CD8+ T cells induce diabetes in RIP-ovahigh or RIP-ovalow recipients unlike similarly treated wild-type cells

cardiovascular system
• following adoptive transfer, CD8+ T cells induce vasculitis within the pancreas in RIP-ovahigh recipients unlike similarly treated wild-type cells

endocrine/exocrine glands
• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ovahigh recipients unlike similarly treated wild-type cells
• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ovahigh recipients unlike similarly treated wild-type cells

hematopoietic system
• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ovalow recipients unlike similarly treated wild-type cells
• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ovahigh recipients unlike similarly treated wild-type cells

cellular
• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ovalow recipients unlike similarly treated wild-type cells
• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ovahigh recipients unlike similarly treated wild-type cells




Genotype
MGI:3687240
cx33
Allelic
Composition
Mapk1tm1Hed/Mapk1tm1Hed
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (43 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

hematopoietic system
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

endocrine/exocrine glands
• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency




Genotype
MGI:4358198
cx34
Allelic
Composition
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Dwu mutation (1 available); any Pik3cg mutation (59 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• naive CD8+ T cell activation, proliferation, and differentiation are normal
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal

hematopoietic system
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal




Genotype
MGI:3783836
cx35
Allelic
Composition
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * C57BL/10Sg * C57BR/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (29 available); any H2 mutation (281 available)
H2k mutation (14 available); any H2 mutation (281 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:5438968
cx36
Allelic
Composition
Slamf6tm1Pls/Slamf6tm1Pls
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf6tm1Pls mutation (1 available); any Slamf6 mutation (33 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cells exhibit normal adhesion to wild-type B cells and B cells lacking Slamf6 (Sh2d1atm1Pls)




Genotype
MGI:3583243
cx37
Allelic
Composition
Tg(Ins2-OVA)307Wehi/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6 * C57BL/6JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-OVA)307Wehi mutation (1 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• doubly transgenic mice begin to exhibit glucosuria as early as 20 days of age; by 70 days, all the mice have urine glucose concentrations greater than 15 mM

renal/urinary system
• doubly transgenic mice begin to exhibit glucosuria as early as 20 days of age; by 70 days, all the mice have urine glucose concentrations greater than 15 mM

immune system
• histological examination of 5 doubly transgenic mice aged 5-68 days revealed heavy lymphocyte infiltration of the pancreatic islets of all mice; 82% of islets, on average, were infiltrated

endocrine/exocrine glands
• severe depletion of beta cells in infiltrated islets of the five mice examined




Genotype
MGI:5581501
cx38
Allelic
Composition
Myo1gtm1.2Mfk/Myo1gtm1.2Mfk
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1gtm1.2Mfk mutation (0 available); any Myo1g mutation (53 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells exhibit decreased antigen detection efficiency compared with wild-type cells

hematopoietic system
• T cells exhibit decreased antigen detection efficiency compared with wild-type cells




Genotype
MGI:7580561
cx39
Allelic
Composition
Rr79em2Rtew/Rr79em2Rtew
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr79em2Rtew mutation (1 available); any Rr79 mutation (1 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells

immune system
• reduced T cell expansion in response to antigen with a higher percentage of terminal effector CD8 cells and lower development of memory T cells




Genotype
MGI:5292731
cx40
Allelic
Composition
Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• after administration of OVA peptide 257-264 has no affect on mortality

liver/biliary system
N
• no morphological abnormalities or increased apoptosis after administration of OVA peptide 257-264
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264

immune system
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264




Genotype
MGI:5811097
cx41
Allelic
Composition
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-NPM/ALK)N1Ingh mutation (0 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• means survival of 181 days

neoplasm
• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas
• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation
• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma
• tumors do not show endogenous TCRbeta rearrangements
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development and develop hepatocellular carcinomas and sarcomas
• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas

digestive/alimentary system
• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas

endocrine/exocrine glands
• total thymic cellularity is increased
• however, mice have normal T-cell development profiles
• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation
• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma
• tumors do not show endogenous TCRbeta rearrangements
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development

hematopoietic system
• total thymic cellularity is increased
• however, mice have normal T-cell development profiles
• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation
• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma
• tumors do not show endogenous TCRbeta rearrangements
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development
• increase in cellular proliferation of the DN3 population

immune system
• total thymic cellularity is increased
• however, mice have normal T-cell development profiles
• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation
• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma
• tumors do not show endogenous TCRbeta rearrangements
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development
• increase in cellular proliferation of the DN3 population

liver/biliary system
• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development and develop hepatocellular carcinomas and sarcomas




Genotype
MGI:5292730
tg42
Allelic
Composition
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
either: C57BL/6 or (involves: C57BL/6 * SJL)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• development of B16.MO5 tumors engineered to express OVA is delayed relative to control mice
• ovalbumin mRNA is not present in tumors although it is present in control tumors
• ovalbumin expression is restored in tumor cells when re-isolated and cultured




Genotype
MGI:3783776
tg43
Allelic
Composition
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb
• when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection
• the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage (J:92867)
• the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells (J:133645)
• there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells (J:92867)
• the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells (J:133645)
• there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice
• there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus
• all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb
• the CD8 single positive T cells in the thymus express high levels of the transgenic TCR
• CD8 T cells make up 20% of the total number of cells in the thymus (J:92867)
• there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice (J:133645)
• OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes (J:133645)
• there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus (J:133645)
• CD8 T cells have high cytolytic activity toward target cells containing OVA peptide (J:92867)
• activated CD8 T cells are strongly cytolytic to cells containing OVA peptide (J:133645)

hematopoietic system
• CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb
• when OVA peptide is included in fetal thymic organ culture, almost all double-positive T cells are clonally deleted as a result of negative selection
• the transgenic T cell receptor (TCR) has high affinity for the H2-Kb allele that leads to increased positive selection of T cell precursors for the CD8 T cell lineage (J:92867)
• the transgenic TCR is positively selected for on this genetic background based on high expression of the TCR on peripheral CD8 T cells (J:133645)
• there is significant skewing in the CD4:CD8 ratio of the thymus towards CD8 single positive T cells (J:92867)
• the ratio of CD4- to CD8- T cells in the periphery is strongly skewed to CD8 T cells (J:133645)
• there is approximately a 7-fold reduction in the number of CD4 T cells in the spleen and lymph nodes of 9 week old mice
• there is almost a 5-fold decrease in the percentage of single positive CD4 T cells found in the thymus
• all CD8 single positive T cells in the thymus express the transgenic TCR that is specific for OVA peptide in the context of H2-Kb
• the CD8 single positive T cells in the thymus express high levels of the transgenic TCR
• CD8 T cells make up 20% of the total number of cells in the thymus (J:92867)
• there is about a 2-fold increase in the number of CD8 T cells in the spleen and lymph nodes of 9 week old mice (J:133645)
• OVA-specific CD8 T cells make up 50% of the cells found in lymph nodes (J:133645)
• there is over a 6-fold increase in the percentage of single positive CD8 T cells found in the thymus (J:133645)
• CD8 T cells have high cytolytic activity toward target cells containing OVA peptide (J:92867)
• activated CD8 T cells are strongly cytolytic to cells containing OVA peptide (J:133645)

cellular
• CD8 single positive T cells of the thymus proliferate vigorously in response to OVA peptide in the context of H2-Kb




Genotype
MGI:5292729
tg44
Allelic
Composition
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increased mortality after administration of OVA peptide 257-264

liver/biliary system
• extensive apoptosis develops after administration of OVA peptide 257-264
• extensive cell death
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264
• CD8+ lymphocytes spike 3 days after administration of OVA peptide 257-264
• become pale and friable by the second day after administration of OVA peptide 257-264

immune system
• extensive infiltration of Valpha2+ CD8+ lymphocytes after administration of OVA peptide 257-264
• CD8+ lymphocytes spike 3 days after administration of OVA peptide 257-264

homeostasis/metabolism
• increased mortality after administration of OVA peptide 257-264

cellular
• extensive apoptosis develops after administration of OVA peptide 257-264
• extensive cell death





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory