All Phenotypes Casp8<tm1Wll> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1	MGI:3055107
cn2	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Alb1-cre)7Gsc/0	involves: 129S1/Sv * 129X1/SvJ * MF1	MGI:3055104
cn3	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Tie1-cre)9Ref/0	involves: 129S1/Sv * 129X1/SvJ * MF1	MGI:3055108
cn4	Casp8^tm1Wll/Casp8^tm1.1Yuan Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129S1/Sv * 129X1/SvJ * MF1	MGI:3055111

Allelic Composition	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1.1Yuan mutation (0 available); any Casp8 mutation (45 available)
Casp8^tm1Wll mutation (0 available); any Casp8 mutation (45 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:92722 )

• unlike mice that do not carry Casp8^tm1.1Yuan, compound heterozygous mutants survive injection with an anti-Fas Ab

hematopoietic system

abnormal myeloblast morphology/development ( J:92722 )

• 2 days after induction of cre expression the ability of progenitor cells to form myeloid or B lymphoid colonies in culture or in transplant studies is significantly decreased

• the ability of these progenitors to differentiate into macrophages is also decreased after induction of cre expression

Allelic Composition	Casp8^tm1Wll/Casp8^tm1.1Yuan Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:92722 )

• unlike mice that do not carry Casp8^tm1.1Yuan, compound heterozygous mutants survive after injection with an anti-Fas Ab

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:92722 )

• unlike mice that do not carry Casp8^tm1.1Yuan, compound heterozygous mutants survive and do not display liver damage after injection with an anti-Fas Ab

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92722 )

• compound heterozygotes die around E12, similar to Casp8^tm1.1Yuan homozygotes

cardiovascular system

abnormal vitelline vasculature morphology ( J:92722 )

• the density of the vasculature in the yolk sac is decreased

visceral vascular congestion ( J:92722 )

• severe congestion of the liver and large vessels of the chest and abdomen similar to Casp8^tm1.1Yuan homozygotes is seen

myocardium necrosis ( J:92722 )

• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

globular heart ( J:92722 )

• the heart has a globose shape

thin ventricular wall ( J:92722 )

• around E12 thin and occasionally ruptured ventricular walls are seen

• heart defects are not seen in mutants at E10-E11.5

pericardial edema ( J:92722 )

• around E12, the pericardial space is enlarged consistent with pericardial edema

muscle

myocardium necrosis ( J:92722 )

• extensive necrosis of the cardiomyocytes in the ventricles and atria is seen

embryo

abnormal vitelline vasculature morphology ( J:92722 )

• the density of the vasculature in the yolk sac is decreased

wavy neural tube ( J:92722 )

• an undulated neural tube is seen

abnormal visceral yolk sac morphology ( J:92722 )

• the density of the vasculature and amount of blood in the yolk sac is decreased

• increased cell death is seen in the yolk sac at E10.5 even when no signs of vascular degeneration were detected

hematopoietic system

hematopoietic system phenotype ( J:92722 )

N	• hematopoietic progenitor numbers are not decreased unlike in Casp8^tm1.1Yuan homozygotes

homeostasis/metabolism

pericardial edema ( J:92722 )

• around E12, the pericardial space is enlarged consistent with pericardial edema

nervous system

wavy neural tube ( J:92722 )

• an undulated neural tube is seen

Allelic Composition	Casp8^tm1Wll/Casp8^tm1.1Yuan Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal macrophage differentiation ( J:92722 )

• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages

• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

immune system

abnormal macrophage differentiation ( J:92722 )

• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages

• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

cellular

abnormal macrophage differentiation ( J:92722 )

• the number monocyte progenitors is not decreased; however, recombined progenitors can not differentiate into macrophages

• the ability of bone marrow progenitors to differentiate into granulocytes is not impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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