Analysis Tools
hematopoietic system
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• CD4+ T cell development is normal in these mice
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• peritoneal macrophages have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide
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immune system
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• CD4+ T cell development is normal in these mice
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• splenic APC have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide
• LPS-induced blasts and peritoneal macrophages are also poor stimulators
• these splenic APC are also poor stimulators for freshly isolated T cells collected from immunized mice
• chemically fixed APC are also poor stimulators to T cell hybridomas when cognate peptide is loaded under neutral pH conditions
• however, chemically fixed APC are excellent stimulators when cognate peptide is loaded under acidic (pH 5) conditions
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• peritoneal macrophages have an impaired capacity to activate I-Ab-restricted T cell hybridomas when loaded with the cognate peptide
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