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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2-Insl3)4Imad
transgene insertion 4, Ibrahim M Adham
MGI:3054956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rxfp1tm1Aia/Rxfp1tm1Aia
Tg(Ins2-Insl3)4Imad/0 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3054986
tg2
 		Tg(Ins2-Insl3)4Imad/0 involves: FVB/N MGI:3054988


Genotype
MGI:3054986
cx1
Allelic
Composition		 Rxfp1tm1Aia/Rxfp1tm1Aia
Tg(Ins2-Insl3)4Imad/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Tg(Ins2-Insl3)4Imad mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased nipple size ( J:92627 )
• mutant females have small nipples
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

reproductive system
ectopic ovary ( J:92627 )
• the ovaries descend into a low intra-abdominal position similar to Tg(Ins2-Insl3)4Imad hemizygotes
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes

integument
decreased nipple size ( J:92627 )
• mutant females have small nipples
abnormal lactation ( J:92627 )
• about 2/3 of the mutant females are unable to nurse pups

skeleton
abnormal gubernaculum morphology ( J:92627 )
• abnormal development of the gubernaculum results in descent of the ovaries similar to Tg(Ins2-Insl3)4Imad hemizygotes




Genotype
MGI:3054988
tg2
Allelic
Composition		 Tg(Ins2-Insl3)4Imad/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ectopic ovary ( J:74295 )
• the ovaries descend into a low intra-abdominal position over the bladder, the presence of a well developed cranial suspensory ligament prevents further descent of the ovaries
• treatment with dihydrotestosterone from E12.5 to E17.5 results in descent of the ovaries into the groin

reproductive system
ectopic ovary ( J:74295 )
• the ovaries descend into a low intra-abdominal position over the bladder, the presence of a well developed cranial suspensory ligament prevents further descent of the ovaries
• treatment with dihydrotestosterone from E12.5 to E17.5 results in descent of the ovaries into the groin
abnormal gubernaculum morphology ( J:74295 )
• abnormal development of the gubernaculum, with a shorter cord and enlarged bulb, results in descent of the ovaries
reduced female fertility ( J:74295 )
• litter size is significantly smaller in transgenic females compared to wild-type however the percent of transgenic and wild-type pups does not differ from the expected ratio
• litter size is normal at E8.5 but reduced by about half at E10.5, E12.5 and E14

skeleton
abnormal gubernaculum morphology ( J:74295 )
• abnormal development of the gubernaculum, with a shorter cord and enlarged bulb, results in descent of the ovaries




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory