Phenotypes associated with this allele

• Allele Symbol: Tg(BCL2OVARY)1Ah
• Allele Name: transgene insertion 1, Aaron Hsueh
• Allele ID: MGI:3054960
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(BCL2OVARY)1Ah/0	involves: FVB	MGI:3835031

Genotype
MGI:3835031

tg1

• Allelic Composition: Tg(BCL2OVARY)1Ah/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased male germ cell number ( J:134106 )

♂

increased male germ cell apoptosis ( J:134106 )

♂ • increased 3.8-fold compared to in wild-type mice

decreased granulosa cell apoptosis ( J:55158 )

♀ • granulose cell apoptosis is rare compared to in wild-type atretic follicles

increased ovarian teratoma incidence ( J:55158 )

♀ • 4 of 20 aged mice develop benign ovarian cystic teratomas compared to none of 26 wild-type mice

abnormal seminiferous tubule morphology ( J:134106 )

♂ • mice exhibit varying degrees of tubular damage with atrophic tubules lined by single layers of cells consisting of Sertoli cells and a few spermatogonia unlike in wild-type mice

abnormal Sertoli cell morphology ( J:134106 )

♂ • unlike in wild-type cells, large vacuoles are found within the cytoplasm

♂ • however, no increase in Sertoli cell apoptosis is detected

decreased testis weight ( J:134106 )

♂ • by 34%

abnormal spermatogenesis ( J:134106 )

♂ • maturation at the spermatid phase is reduced 56% compared to in wild-type mice

abnormal spermatid morphology ( J:134106 )

♂

increased superovulation rate ( J:55158 )

♀ • 61% of PMSG-treated mice exhibit spontaneous ovulation compared to 17% of similarly treated wild-type mice

increased litter size ( J:55158 )

• PMSG-treated mice produce larger litters than similarly treated wild-type mice

neoplasm

increased ovarian teratoma incidence ( J:55158 )

♀ • 4 of 20 aged mice develop benign ovarian cystic teratomas compared to none of 26 wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:55158 )

• pregnant mare's serum gonadotrophin (PMSG)-treated mice exhibit a 57% suppression of induced follicular apoptosis compared to similarly treated wild-type mice

• 61% of PMSG-treated mice exhibit spontaneous ovulation compared to 17% of similarly treated wild-type mice

• PMSG-treated mice produce larger litters than similarly treated wild-type mice

endocrine/exocrine glands

decreased granulosa cell apoptosis ( J:55158 )

♀ • granulose cell apoptosis is rare compared to in wild-type atretic follicles

increased ovarian teratoma incidence ( J:55158 )

♀ • 4 of 20 aged mice develop benign ovarian cystic teratomas compared to none of 26 wild-type mice

abnormal seminiferous tubule morphology ( J:134106 )

♂ • mice exhibit varying degrees of tubular damage with atrophic tubules lined by single layers of cells consisting of Sertoli cells and a few spermatogonia unlike in wild-type mice

abnormal Sertoli cell morphology ( J:134106 )

♂ • unlike in wild-type cells, large vacuoles are found within the cytoplasm

♂ • however, no increase in Sertoli cell apoptosis is detected

decreased testis weight ( J:134106 )

♂ • by 34%

cellular

abnormal spermatid morphology ( J:134106 )

♂

decreased male germ cell number ( J:134106 )

♂

increased male germ cell apoptosis ( J:134106 )

♂ • increased 3.8-fold compared to in wild-type mice

decreased granulosa cell apoptosis ( J:55158 )

♀ • granulose cell apoptosis is rare compared to in wild-type atretic follicles