Analysis Tools
mortality/aging
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• unable to tolerate ascending aortic constriction (AAC) around a 27-gauge needle
• some mice die within 48 h postop of AAC using a 25-gauge needle
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cardiovascular system
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• aortas from angiotensin II (AngII) infused mice display abnormalities consistent with induced aortopathy
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• blunted adventitial growth response to AngII
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• abnormalities induced by AngII infusion include severe disruption of medial architecture characterized by prominent elastolysis, increased SMC apoptosis and reduced medial thickness
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• mild medial hypertrophy
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• following AngII infusion
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• in some mice following AngII infusion
• development of abdominal aortic aneurysms is more common than development of thoracic aortic aneurysms
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• in some mice following AngII infusion
• development of abdominal aortic aneurysms is more common than development of thoracic aortic aneurysms
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• unlike in wild-type mice, AngII infusion fails to increase myocardial capillary density
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• following AAC with a 25-gauge needle myocytes are larger in area, longer and slightly narrower
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• infusion of AngII induces cardiomegaly
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• mild
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• increase in cavity size at 12-16 weeks of age
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• following AAC with a 25-gauge needle
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• after AngII infusion, 35% of mice develop aortic aneurysm compared to 0% in wild-type mice
• development of abdominal aortic aneurysms is more common than development of thoracic aortic aneurysms
• some aneurysms develop intramural hematomas
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• decrease in left ventricular fractional shortening at 12-16 weeks of age
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• unable to tolerate AAC around a 27-guage needle
(J:121109)
• some mice die within 48 h postop of AAC using a 25-gauge needle
(J:121109)
• AAC with a 25-gauge needle induces marked left ventricular dilation and reduction in systolic function
(J:121109)
• hearts fail to increase left ventricular wall thickness following AAC with a 25-gauge needle
(J:121109)
• increased sensitivity of the heart and aorta to AngII infusion
(J:167880)
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• infusion of AngII induces severe cardiomyopathy characterized by cardiomegaly, LV dysfunction, and cavity dilation with attenuated wall thickening
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homeostasis/metabolism
| N |
• despite abnormalities in glucose homeostasis, no abnormalities in insulin levels are detected
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• unable to tolerate AAC around a 27-guage needle
(J:121109)
• some mice die within 48 h postop of AAC using a 25-gauge needle
(J:121109)
• AAC with a 25-gauge needle induces marked left ventricular dilation and reduction in systolic function
(J:121109)
• hearts fail to increase left ventricular wall thickness following AAC with a 25-gauge needle
(J:121109)
• increased sensitivity of the heart and aorta to AngII infusion
(J:167880)
|
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• increase in the concentrations of several amino acids including proline, tyrosine, leucine and valine
• decrease in the concentration of glutamine
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• small but significant decrease in blood glucose in ad libitum fed males and females compared to wild-type controls
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hypoglycemia
(
J:129763
)
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• severe hypoglycemia after a 15h fast
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• in mice fasted for 18 h compared to similarly fasted wild-type mice
• however, no difference is detected in the fed state
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• elevated levels of beta-hydroxybutyrate in fasted mice
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• mild decrease in serum lactate levels in fed and fasted mice
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• during insulin clamp hepatic glucose production is reduced by 60% compared to controls
• significantly less efficient at utilizing alanine as a gluconeogenic substrate
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• mice fasted for 16h clear glucose faster than wild-type controls
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• about 3.5 fold lower in mice fasted for 18 h compared to similarly fasted wild-type mice
• however, no difference is detected in the fed state
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• in fed and fasted mice
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ketoaciduria
(
J:129763
)
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• elevated acetoacetate levels in both fed and fasted mice
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• analysis suggests a decrease in amino acid breakdown
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• about a 2 fold reduction in alanine aminotransferase activity in hepatocytes
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liver/biliary system
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• about 3.5 fold lower in mice fasted for 18 h compared to similarly fasted wild-type mice
• however, no difference is detected in the fed state
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• decrease in alanine aminotransferase activity and glucose production
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adipose tissue
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• decreased fat mass at 4 months of age
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growth/size/body
| N |
• no significant differences in total body weight compared to wild-type mice are detected from 1 - 3.5 months of age
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• infusion of AngII induces cardiomegaly
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• mild
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• at 4 months of age
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muscle
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• following AAC with a 25-gauge needle myocytes are larger in area, longer and slightly narrower
|
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• mild
|
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• decrease in left ventricular fractional shortening at 12-16 weeks of age
|
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• infusion of AngII induces severe cardiomyopathy characterized by cardiomegaly, LV dysfunction, and cavity dilation with attenuated wall thickening
|
renal/urinary system
ketoaciduria
(
J:129763
)
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• elevated acetoacetate levels in both fed and fasted mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| aortic aneurysm | DOID:3627 | J:167880 | ||
