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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-EGFP)D4Nagy
transgene insertion D4, Andras Nagy
MGI:3055027
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523431
cn2
 		Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523432
cn3
 		Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
Tg(CAG-EGFP)D4Nagy/0
Tg(Hmgcr-lacZ)H253Sest/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3826982
cx4
 		Tg(CAG-EGFP)D4Nagy/0
Xisttm5.2Nbd/Xist+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4950463


Genotype
MGI:5523431
cn1
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:198636 )
N
• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father




Genotype
MGI:5523432
cn2
Allelic
Composition		 Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
failure to gastrulate ( J:198636 )
• hemizygous males fail to gastrulate when mutant and cre are derived from the mother and the reporter is derived from the father




Genotype
MGI:3826982
cn3
Allelic
Composition		 Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
Tg(CAG-EGFP)D4Nagy/0
Tg(Hmgcr-lacZ)H253Sest/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hccstm1Tcc mutation (2 available); any Hccs mutation (4 available)
Nkx2-5tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Hmgcr-lacZ)H253Sest mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal fetal cardiomyocyte morphology ( J:143285 )
• at E12.5, the relative volume of abnormal heart tissue begins to decline to 42% in ventricles and 47% in atria and is further reduced at E16.5 to 18% in ventricles and 19% in the atria then 10% in ventricles and 17% in the atria prior to birth
• at E12.5 and E13.5, cardiomyocytes appear small and round compared to wild-type cells
• however, the absolute volume of heart tissue before birth is unchanged
decreased fetal cardiomyocyte size ( J:143285 )
• cardiomyocytes appear smaller at E12.5 and E13.5
abnormal fetal cardiomyocyte proliferation ( J:143285 )
• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner

muscle
abnormal fetal cardiomyocyte proliferation ( J:143285 )
• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner

cellular
abnormal fetal cardiomyocyte proliferation ( J:143285 )
• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner




Genotype
MGI:4950463
cx4
Allelic
Composition		 Tg(CAG-EGFP)D4Nagy/0
Xisttm5.2Nbd/Xist+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Xisttm5.2Nbd mutation (0 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal dosage compensation, by inactivation of X chromosome ( J:171502 )
• when the allele is maternally inherited, mice exhibit secondary non-random X inactivation compared with wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory