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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhotm1(EDNRB)Fji
targeted mutation 1, Yoshinori Fujiyoshi
MGI:3055163
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhotm1(EDNRB)Fji/Rhotm1(EDNRB)Fji involves: 129S1/Sv * C57BL/6J MGI:3581045
ht2
 		Rhotm1(EDNRB)Fji/Rho+ involves: 129S1/Sv * C57BL/6J MGI:3581047


Genotype
MGI:3581045
hm1
Allelic
Composition		 Rhotm1(EDNRB)Fji/Rhotm1(EDNRB)Fji
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1(EDNRB)Fji mutation (0 available); any Rho mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina rod cell outer segment morphology ( J:98779 )
• rod outer segments were absent
retina photoreceptor degeneration ( J:98779 )
• photoreceptors were almost completely degenerated
abnormal retina outer nuclear layer morphology ( J:98779 )
• the outer nuclear layer density was about 37% less than in wildtype

nervous system
abnormal retina rod cell outer segment morphology ( J:98779 )
• rod outer segments were absent
retina photoreceptor degeneration ( J:98779 )
• photoreceptors were almost completely degenerated




Genotype
MGI:3581047
ht2
Allelic
Composition		 Rhotm1(EDNRB)Fji/Rho+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1(EDNRB)Fji mutation (0 available); any Rho mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina rod cell outer segment morphology ( J:98779 )
• rod outer segments were 1/4 the length of wildtype at 15 days of age, 1/2 the length at 30 days of age and comparable to wildtype at 91 days of age

nervous system
abnormal retina rod cell outer segment morphology ( J:98779 )
• rod outer segments were 1/4 the length of wildtype at 15 days of age, 1/2 the length at 30 days of age and comparable to wildtype at 91 days of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory