Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tnfaip3tm1Ama targeted mutation 1, Averil Ma MGI:3055173 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bone marrow derived macrophages produce more TNF, IL-6, and nitric oxide in response to LPS treatment compared to wild-type macrophages
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• the absolute number and percentage of myeloid cells is increased in multiple tissues
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased sensitivity to LPS and TNF induced-lethality are seen
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• homozygotes begin to die after 1 week of age
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
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• homozygotes are runted by 1 week of age
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• increased numbers of activated granulocytes are seen in spleens and livers
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• increased numbers of activated lymphocytes are seen in spleens and livers
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• increased numbers of activated granulocytes are seen in spleens and livers
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• increased numbers of activated granulocytes are seen in spleens and livers
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• increased numbers of activated lymphocytes are seen in spleens and livers
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• increased numbers of activated granulocytes are seen in spleens and livers
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• severe bone marrow inflammation and tissue damage are seen at 3 to 6 weeks of age
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
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• severe inflammation and tissue damage are seen at 3 to 6 weeks of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• bone marrow derived macrophages produce more IL-6 and nitric oxide in response to LPS treatment compared to Tnfaip1tm1Ama heterozygous Tnftm1Gkl homozygous macrophages
|
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• the absolute number and percentage of myeloid cells is increased in multiple tissues
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the absolute number and percentage of myeloid cells is increased in multiple tissues
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the absolute number and percentage of myeloid cells is increased in multiple tissues
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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