About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psmb8tm1Hjf
targeted mutation 1, H J Fehling
MGI:3055222
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psmb8tm1Hjf/Psmb8tm1Hjf either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6) MGI:3622433
hm2
 		Psmb8tm1Hjf/Psmb8tm1Hjf involves: 129P2/OlaHsd MGI:5563852
hm3
 		Psmb8tm1Hjf/Psmb8tm1Hjf involves: 129P2/OlaHsd * C57BL/6 MGI:3624630
cx4
 		Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3622434
cx5
 		Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf 		involves: 129P2/OlaHsd * C57BL/6 MGI:5514417
cx6
 		Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac MGI:5514416


Genotype
MGI:3622433
hm1
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased level of surface class I molecules ( J:20012 )
• reduced MHC class I cell surface antigens
• H-2K and H-2D are about equally reduced
defective intracellular transport of class I molecules ( J:20012 )
• splenocytes with reduced ability to process class I restricted antigens




Genotype
MGI:5563852
hm2
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell antigen presentation ( J:180765 )
• presentation of antigen by dendritic cells in vitro is less able to support proliferation of T cells
decreased level of surface class I molecules ( J:180765 )
• levels are decreased on splenic B cells and dendritic cells




Genotype
MGI:3624630
hm3
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:108550 )
• anti-tumor immunity against Lewis lung carcinoma cells induced by immunization with the DNA vaccine pUB-MUT1 is attenuated in mutant mice compared to comtrol B6




Genotype
MGI:3622434
cx4
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:107657 )
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:107657 )
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell




Genotype
MGI:5514417
cx5
Allelic
Composition		 Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11tm1(Psmb8)Khog mutation (0 available); any Psmb11 mutation (11 available)
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5514416
cx6
Allelic
Composition		 Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11tm1.1(Psmb8)Khog mutation (0 available); any Psmb11 mutation (11 available)
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor V(D)J recombination ( J:196156 )
• altered TCR-V distribution in CD8+ T cells

hematopoietic system
abnormal T cell receptor V(D)J recombination ( J:196156 )
• altered TCR-V distribution in CD8+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory