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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psmb8tm1Hjf
targeted mutation 1, H J Fehling
MGI:3055222
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psmb8tm1Hjf/Psmb8tm1Hjf either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6) MGI:3622433
hm2
 		Psmb8tm1Hjf/Psmb8tm1Hjf involves: 129P2/OlaHsd MGI:5563852
hm3
 		Psmb8tm1Hjf/Psmb8tm1Hjf involves: 129P2/OlaHsd * C57BL/6 MGI:3624630
cx4
 		Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3622434
cx5
 		Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf 		involves: 129P2/OlaHsd * C57BL/6 MGI:5514417
cx6
 		Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac MGI:5514416


Genotype
MGI:3622433
hm1
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased level of surface class I molecules ( J:20012 )
• reduced MHC class I cell surface antigens
• H-2K and H-2D are about equally reduced
defective intracellular transport of class I molecules ( J:20012 )
• splenocytes with reduced ability to process class I restricted antigens




Genotype
MGI:5563852
hm2
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell antigen presentation ( J:180765 )
• presentation of antigen by dendritic cells in vitro is less able to support proliferation of T cells
decreased level of surface class I molecules ( J:180765 )
• levels are decreased on splenic B cells and dendritic cells




Genotype
MGI:3624630
hm3
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:108550 )
• anti-tumor immunity against Lewis lung carcinoma cells induced by immunization with the DNA vaccine pUB-MUT1 is attenuated in mutant mice compared to comtrol B6




Genotype
MGI:3622434
cx4
Allelic
Composition		 Psmb8tm1Hjf/Psmb8tm1Hjf
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:107657 )
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:107657 )
• 30% reduction of CD8+ cells in the thymus
• reductions particularly involve cells expressing transgene coded TCR
• no alterations in CD4+ T cell




Genotype
MGI:5514417
cx5
Allelic
Composition		 Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11tm1(Psmb8)Khog mutation (0 available); any Psmb11 mutation (11 available)
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5514416
cx6
Allelic
Composition		 Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog
Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11tm1.1(Psmb8)Khog mutation (0 available); any Psmb11 mutation (11 available)
Psmb8tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor V(D)J recombination ( J:196156 )
• altered TCR-V distribution in CD8+ T cells

hematopoietic system
abnormal T cell receptor V(D)J recombination ( J:196156 )
• altered TCR-V distribution in CD8+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory