Phenotypes associated with this allele

• Allele Symbol: Tg(PRG1)18Wlad
• Allele Name: transgene insertion 18, Wyeth Lederle/Anne Deatly
• Allele ID: MGI:3055287
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(PRG1)18Wlad/0	involves: C57BL/6J * CBA/J	MGI:3835114

Genotype
MGI:3835114

tg1

• Allelic Composition: Tg(PRG1)18Wlad/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:92990 )

• when infected with wild-type III poliovirus mice exhibit lethality unlike wild-type mice

immune system

decreased susceptibility to Picornaviridae infection ( J:127826 )

• onset of disease following exposure to poliovirus is later than in mice expressing Tg(PRG3)9Wlad

increased susceptibility to Picornaviridae infection ( J:92990 )

• when infected with wild-type III poliovirus mice exhibit paralysis and neuron degeneration unlike wild-type mice

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:92990 )

• when infected with wild-type III poliovirus mice exhibit lethality unlike wild-type mice