Phenotypes associated with this allele

• Allele Symbol: Cd83^lcd4
• Allele Name: low CD4 cell
• Allele ID: MGI:3055293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd83^lcd4/Cd83^lcd4	involves: C57BL/6J	MGI:3055725

Genotype
MGI:3055725

hm1

• Allelic Composition: Cd83^lcd4/Cd83^lcd4
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:92721 )

• CD4+ cell proliferation in a mixed lymphocyte reaction is impaired, however addition of IL-2 to the culture restores CD4+ cell proliferation to normal

abnormal CD4-positive T cell differentiation ( J:92721 )

• CD4+ cell development is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:92721 )

• under maximal stimulation conditions CD4+ cells produce less IL-2 and more IL-4 and IL-10, however under suboptimal conditions these cells produce more IL-2 compared to wild-type

immune system

decreased T cell proliferation ( J:92721 )

• CD4+ cell proliferation in a mixed lymphocyte reaction is impaired, however addition of IL-2 to the culture restores CD4+ cell proliferation to normal

abnormal CD4-positive T cell differentiation ( J:92721 )

• CD4+ cell development is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:92721 )

• under maximal stimulation conditions CD4+ cells produce less IL-2 and more IL-4 and IL-10, however under suboptimal conditions these cells produce more IL-2 compared to wild-type

decreased susceptibility to type IV hypersensitivity reaction ( J:92721 )

• little or no ear swelling is seen in a contact hypersensitivty assay

cellular

decreased T cell proliferation ( J:92721 )

• CD4+ cell proliferation in a mixed lymphocyte reaction is impaired, however addition of IL-2 to the culture restores CD4+ cell proliferation to normal