Phenotypes associated with this allele

• Allele Symbol: Tekt2^{Gt(OST12401)Lex}
• Allele Name: gene trap OST12401, Lexicon Genetics
• Allele ID: MGI:3055308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tekt2^Gt(OST12401)Lex/Tekt2^Gt(OST12401)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3055324

Genotype
MGI:3055324

hm1

• Allelic Composition: Tekt2^{Gt(OST12401)Lex}/Tekt2^{Gt(OST12401)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm axoneme morphology ( J:92779 )

♂ • all male homozygotes studied show a partial deficiency or loss of the inner dynein arm structures in the flagellar axonemes of sperm

hairpin sperm flagellum ( J:92779 )

♂ • more than 70% of sperm have abnormally bent or curved flagella

asthenozoospermia ( J:92779 )

♂ • reduced sperm motility is seen and no sperm are found in the oviducts after mating with wild-type females

male infertility ( J:92779 )

♂ • male but not female homozygotes are infertile

♂ • sperm from homozygous males can fertilize oocytes in vitro

respiratory system

abnormal respiratory motile cilium morphology ( J:92779 )

• tracheal cilia display abnormal morphology

• inner dynein arms are lacking at position 3 and at positions 6, 7, and 9

abnormal respiratory motile cilium physiology ( J:92779 )

• severe defects in carbon particle exclusion from the bottom of the trachea due to impaired cilia motility

abnormal tracheal ciliated epithelium morphology ( J:92779 )

• ciliary morphology is abnormal with sporadic absence of the inner dynein arms

abnormal mucociliary clearance ( J:92779 )

• carbon particle exclusion from the bottom of the trachea is severely impaired

cellular

abnormal respiratory motile cilium morphology ( J:92779 )

• tracheal cilia display abnormal morphology

• inner dynein arms are lacking at position 3 and at positions 6, 7, and 9

abnormal sperm axoneme morphology ( J:92779 )

♂ • all male homozygotes studied show a partial deficiency or loss of the inner dynein arm structures in the flagellar axonemes of sperm

hairpin sperm flagellum ( J:92779 )

♂ • more than 70% of sperm have abnormally bent or curved flagella

asthenozoospermia ( J:92779 )

♂ • reduced sperm motility is seen and no sperm are found in the oviducts after mating with wild-type females

abnormal respiratory motile cilium physiology ( J:92779 )

• severe defects in carbon particle exclusion from the bottom of the trachea due to impaired cilia motility