Analysis Tools
nervous system
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• increased sensitivity to kainic acid induced excitotoxic injury in the hippocampal CA3 region, resulting in increased cell death
• hippocampal neurons, but not cerebellar granule neurons, were more sensitive to undergo cell degeneration in response to cell death inducers such as thapsigargin, compared to wildtype
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• exhibited an increase in neuron degeneration in the brain cortex at 12 months of age but not at 4 months of age
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• increase in neuron degeneration in the hilus and dentate gyrus region of the hippocampus at 12 months of age but not at 4 months of age, indicating age-dependent neurodegeneration
• hippocampal neurons, but not cerebellar granule neurons, were more sensitive to undergo cell degeneration in response to cell death inducing compounds such as thapsigargin, compared to wildtype
• decrease in cell viability of cultured hippocampal neurons with time
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homeostasis/metabolism
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• increased sensitivity to kainic acid induced excitotoxic injury in the hippocampal CA3 region, resulting in increased cell death
• hippocampal neurons, but not cerebellar granule neurons, were more sensitive to undergo cell degeneration in response to cell death inducers such as thapsigargin, compared to wildtype
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cellular
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• increased sensitivity to kainic acid induced excitotoxic injury in the hippocampal CA3 region, resulting in increased cell death
• hippocampal neurons, but not cerebellar granule neurons, were more sensitive to undergo cell degeneration in response to cell death inducers such as thapsigargin, compared to wildtype
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