All Phenotypes Stat5a<tm2Mam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stat5a^tm2Mam
targeted mutation 2, Lothar Hennighausen
MGI:3055318

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR	MGI:4839921
cn2	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Nes-cre)1Kln/0	involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL	MGI:4840275
cn3	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	MGI:4840248
cn4	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac	MGI:4840214
cn5	Myf5^tm3(cre)Sor/Myf5⁺ Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)1Dlr/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N	MGI:4840222
cn6	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * Black Swiss	MGI:3055364
cn7	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0	involves: 129S6/SvEvTac * Black Swiss * FVB	MGI:3055363
cn8	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2	MGI:4843433
cn9	Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺ Stat5a^tm2Mam Stat5b^tm1Mam/Del(11Stat5a-Stat5b)1Mam Tg(Mx1-cre)1Cgn/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA	MGI:5544442
cn10	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Pdx1-cre)89.1Dam/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4840009
cn11	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Mx1-cre)1Cgn/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4847917
cn12	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Ins2-cre)25Mgn/0	involves: 129S6/SvEvTac * C57BL/6 * DBA	MGI:4840005
cn13	Stat5a^tm2Mam/Stat5a^tm2Mam Tg(Ins2-cre)23Herr/0	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:6400803
cn14	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:4847637
cn15	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4844105
cn16	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0	involves: 129S6/SvEvTac * FVB/N	MGI:4840246
cn17	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0	involves: 129S6/SvEvTac * FVB/N	MGI:4847555
cx18	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b⁺	involves: 129S6/SvEvTac	MGI:6150449
cx19	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam	involves: 129S6/SvEvTac * Black Swiss	MGI:3055361

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

abnormal acute inflammation ( J:122463 )

• lymphoid organ infiltration starting at the age of 4 weeks

hematopoietic system

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

abnormal T cell subpopulation ratio ( J:122463 )

• increased ratio of CD4+ versus CD8+ cells in thymus, peripheral blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:122463 )

• reduction of CD8+ T cells in thymus, peripheral blood, spleen and lymph nodes

growth/size/body

enlarged spleen ( J:122463 )

• splenomegaly starting at the age of 4 weeks

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased lean body mass ( J:132806 )

• increase 40% and 20% in male and female mice, respectively at 22 weeks of age

obese ( J:132806 )

• gain more weight than control littermates starting from 8 weeks of age

• more profound after 16 weeks of age

• weigh on the average 65% (males) and 60% (females) more at 26 weeks of age

behavior/neurological

polyphagia ( J:132806 )

• increased food intake in male at 16 weeks of age

• increased food intake in both male and female at 26 weeks of age

homeostasis/metabolism

impaired adaptive thermogenesis ( J:132806 )

• reduced cold tolerance at 26 weeks of age

increased circulating insulin level ( J:132806 )

• 8-fold at 22 weeks of age

increased circulating leptin level ( J:132806 )

• 4.5-fold at 22 weeks of age

increased circulating free fatty acids level ( J:132806 )

• at 22 weeks of age

increased circulating triglyceride level ( J:132806 )

• at 22 weeks of age

decreased oxygen consumption ( J:132806 )

• reduced oxygen consumption normalized to lean mass in male mice at 26 weeks of age

impaired glucose tolerance ( J:132806 )

• at 22 weeks of age

insulin resistance ( J:132806 )

• at 22 weeks of age

adipose tissue

increased total body fat amount ( J:132806 )

• increase 2.5- and 3.5-fold in male and female mice, respectively at 22 weeks of age

• increase in both subcutaneous and visceral fat mass

abnormal fat pad morphology ( J:132806 )

• larger mean cross-sectional areas of adipocytes in inguinal, parametrial and mesenteric fat pads

increased total fat pad weight ( J:132806 )

• at least 2 fold increase in weight of all 5 fat pads (inguinal, parametrial, retroperitoneal, mesenteric and perirenal)

increased percent body fat/body weight ( J:132806 )

• 150% and 200% in male and female mice, respectively of that measured in control mice at 22 weeks of age

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:121556 )

• reduced body weight starting around 3 weeks of age

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased lean body mass ( J:119237 )

• reduced lean mass at 8 weeks of age

• normal fraction of lean mass to total body weight

decreased body weight ( J:119237 )

• 12% and 20% smaller for female and male mice respectively, at 8 weeks of age

decreased body length ( J:119237 )

• reduced body length at 8 weeks of age

adipose tissue

increased total body fat amount ( J:119237 )

• a trend toward higher total fat mass at 8 weeks of age

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:119237 )

• 15% decrease in circulating IGF-I level at 8 weeks of age

increased circulating triglyceride level ( J:119237 )

• elevated serum triglycerides at 8 weeks of age

impaired glucose tolerance ( J:119237 )

• glucose intolerance in male mice at 30- and 60-min after glucose challenge

• a similar trend in female, but less severe

Allelic Composition	Myf5^tm3(cre)Sor/Myf5⁺ Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased lean body mass ( J:119237 )

• reduced lean mass at 8 weeks of age

• reduction in fraction of lean mass at 8 weeks of age

decreased body weight ( J:119237 )

• 12% and 20% smaller for female and male mice respectively, at 8 wk of age

decreased body length ( J:119237 )

• reduced body length at 8 weeks of age

adipose tissue

increased total body fat amount ( J:119237 )

• modest increase in body fat at 8 weeks of age

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:119237 )

• 60% decrease in circulating IGF-I level at 8 weeks of age

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

abnormal mammary gland epithelium physiology ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

abnormal mammary gland epithelium physiology ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * FVB

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

• the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

• treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological

abnormal milk ejection ( J:92770 )

• 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating interleukin-17 level ( J:120176 )

• elevated serum IL-17 concentration

immune system

increased circulating interleukin-17 level ( J:120176 )

• elevated serum IL-17 concentration

increased interleukin-17 secretion ( J:120176 )

• increased amounts of IL-17 protein in the culture supernatants of CD4+ T cells activated with anti-CD3 and anti-CD28

Allelic Composition	Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺ Stat5a^tm2Mam Stat5b^tm1Mam/Del(11Stat5a-Stat5b)1Mam Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Stat5a-Stat5b)1Mam mutation (0 available); any Del(11Stat5a-Stat5b)1Mam mutation (0 available)
Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} mutation (11 available); any Gt(ROSA)26Sor mutation (993 available)
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:204829 )

• fewer IL9+ cells in IFN-alpha-treated mice following differentiation towards Th9 lineage

immune system

abnormal CD4-positive T cell differentiation ( J:204829 )

• fewer IL9+ cells in IFN-alpha-treated mice following differentiation towards Th9 lineage

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

disorganized pancreatic islets ( J:127051 )

• disrupted architecture of islets as evidenced by the migration of glucagon-expressing alpha-cells into the central region of the islets

homeostasis/metabolism

impaired glucose tolerance ( J:127051 )

• mild glucose intolerance in mice older than 6 months

• slightly more glucose intolerant during pregnancy than their control littermates

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:155489 )

• increased cell death in GMPs and their progeny during culture with GM-CSF up to the fifth generation

abnormal neutrophil differentiation ( J:155489 )

• no elevation of neutrophils 18 days after induced myelosuppression by 5-FU injection

• severely impaired GM-CSF-induced increase of peripheral blood neutrophils

decreased cell proliferation ( J:155489 )

• longer generation times in every generation (F1 through F4) during culture with GM-CSF compared with control cells

hematopoietic system

abnormal leukopoiesis ( J:155489 )

• decreased absolute number of bone marrow mononuclear cells (BMMNCs) from both femora and tibiae per mouse

• decreased absolute number of granulocyte-macrophage progenitors (GMPs) from both femora and tibiae per mouse

• impaired colony formation of GMPs

• reduced numbers of mutant colonies by more than 50% in the presence of GM-CSF

• the average cell number of a mutant GMP-derived colony is only 11% of that from control GMPs

• normal percentage of GMPs in BMMNCs

abnormal neutrophil differentiation ( J:155489 )

• no elevation of neutrophils 18 days after induced myelosuppression by 5-FU injection

• severely impaired GM-CSF-induced increase of peripheral blood neutrophils

anemia ( J:155489 )

decreased erythrocyte cell number ( J:155489 )

decreased hematocrit ( J:155489 )

decreased hemoglobin content ( J:155489 )

decreased leukocyte cell number ( J:155489 )

• decreased white blood cell counts

decreased neutrophil cell number ( J:155489 )

• decreased absolute number of peripheral neutrophils by 50% in homeostasis 3 weeks after PolyIC injection

decreased lymphocyte cell number ( J:155489 )

• decreased lymphocytes counts (70% decrease)

decreased monocyte cell number ( J:155489 )

• decreased monocytes counts (44% decrease)

abnormal neutrophil physiology ( J:155489 )

• only 65% of mutant bone marrow neutrophils, compare with virtually all cells from control animals survive for 36 hours in the presence of GM-CSF

immune system

abnormal leukopoiesis ( J:155489 )

• decreased absolute number of bone marrow mononuclear cells (BMMNCs) from both femora and tibiae per mouse

• decreased absolute number of granulocyte-macrophage progenitors (GMPs) from both femora and tibiae per mouse

• impaired colony formation of GMPs

• reduced numbers of mutant colonies by more than 50% in the presence of GM-CSF

• the average cell number of a mutant GMP-derived colony is only 11% of that from control GMPs

• normal percentage of GMPs in BMMNCs

abnormal neutrophil differentiation ( J:155489 )

• no elevation of neutrophils 18 days after induced myelosuppression by 5-FU injection

• severely impaired GM-CSF-induced increase of peripheral blood neutrophils

decreased leukocyte cell number ( J:155489 )

• decreased white blood cell counts

decreased neutrophil cell number ( J:155489 )

• decreased absolute number of peripheral neutrophils by 50% in homeostasis 3 weeks after PolyIC injection

decreased lymphocyte cell number ( J:155489 )

• decreased lymphocytes counts (70% decrease)

decreased monocyte cell number ( J:155489 )

• decreased monocytes counts (44% decrease)

abnormal neutrophil physiology ( J:155489 )

• only 65% of mutant bone marrow neutrophils, compare with virtually all cells from control animals survive for 36 hours in the presence of GM-CSF

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:127051 )

• mild obesity

• weigh on the average 20% more than their control littermates by 9 months of age

adipose tissue

increased total body fat amount ( J:127051 )

• elevated adipose tissue mass of female mice

• normal lean mass

homeostasis/metabolism

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose

increased circulating glucose level ( J:127051 )

• slightly elevated serum glucose levels at 7 months of age

increased circulating leptin level ( J:127051 )

• higher serum leptin levels at 7 months of age

• normal serum insulin levels

increased circulating free fatty acids level ( J:127051 )

• higher serum free fatty acids levels at 7 months of age

impaired glucose tolerance ( J:127051 )

• higher glucose levels than the controls at all time points after glucose injection

• severity of impaired glucose response increases in both female and male mice as they age

• more severe than that seen in Tg(Ins2-cre)25Mgn mice

endocrine/exocrine glands

disorganized pancreatic islets ( J:127051 )

• disrupted architecture of islets as evidenced by the migration of glucagon-expressing alpha-cells into the central region of the islets

decreased insulin secretion ( J:127051 )

• reduced insulin secretion from isolated islets upon challenge with 16.7 mM of glucose

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:284574 )

decreased pancreatic beta cell mass ( J:284574 )

homeostasis/metabolism

decreased serotonin level ( J:284574 )

• undetectable at P0

cellular

decreased pancreatic beta cell proliferation ( J:284574 )

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

reproductive system

reproductive system phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hypochromic microcytic anemia ( J:138904 )

• microcytic, hypochromic anemia

decreased erythroid progenitor cell number ( J:138904 )

• red cell hypoplasia in bone marrow at E18.5

abnormal proerythroblast morphology ( J:138904 )

• higher ratio of nucleated erythroid cells in fetuses and neonates

decreased erythrocyte cell number ( J:138904 )

• greatly reduced number of mature red blood cells in fetuses and neonates

decreased hematocrit ( J:138904 )

• decreased hematocrits of approximately 2.5 (25%) in neonates, compared with 4.7 (47%) in controls

• hematocrits in adult mutant mice remain low at 2.9

• decreased hematocrits of approximately 2.6 in mice that receive a transplant of mutant fetal liver cells, compared with 3.8 in controls

decreased mean corpuscular hemoglobin ( J:138904 )

• reduced red cell size (mean corpuscular volume) and hemoglobin content in mutant mice and in mice that receive a transplant of mutant fetal liver cells

increased red blood cell distribution width ( J:138904 )

• increased red cell distribution width

anisocytosis ( J:138904 )

microcytosis ( J:138904 )

poikilocytosis ( J:138904 )

reticulocytosis ( J:138904 )

homeostasis/metabolism

increased circulating iron level ( J:138904 )

• elevated serum iron levels and transferrin saturation in mutant mice and in mice that receive a transplant of mutant fetal liver cells

increased liver iron level ( J:138904 )

• non-heme iron overload in the liver

• periportal hepatocyte iron staining

cellular

increased apoptosis ( J:138904 )

• elevated cell death in survival response of splenic Ter119-positive cells to erythropoietin

liver/biliary system

increased liver iron level ( J:138904 )

• non-heme iron overload in the liver

• periportal hepatocyte iron staining

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:121556 )

• reduced body weight starting around 3 weeks of age

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

integument

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b⁺
Genetic Background	involves: 129S6/SvEvTac

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphopoiesis ( J:258967 )

• impaired NK cell maturation

hematopoietic system

abnormal lymphopoiesis ( J:258967 )

• impaired NK cell maturation

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:92770 )

• homozygotes are indistinguishable from wild-type littermates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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