Analysis Tools
mortality/aging
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• approximately 1% of the mice reach weaning age, and die within the first 6 weeks after birth
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• most of the mice die perinatally
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growth/size/body
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• mice surviving to weaning age are smaller than their littermates
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• reduced body weight in survivor mice at the age of 4 weeks
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respiratory system
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• reduced lung capacity
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immune system
small thymus
(
J:122463
)
|
• smaller thymus than that would be expected from the body size and age of the mice
|
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• B-cell development is arrested at the pre-pro-B-cell stage in survivor mice and in fetal liver-derived cultures
• no pro-B, immature, and mature B cells in cultures derived from fetal livers
• no early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively)
• reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively)
• few mature B-lymphoid cells are present in the periphery
|
|
• no early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively)
• reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively)
• few mature B-lymphoid cells are present in the periphery
|
|
• reduction of CD8+ T cells (2.5-fold) in the thymus
• reduction of CD8+ T cells (12-fold) in the lymph nodes
|
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• absent CD4- CD8- gamma-delta TCR+ cells in the thymic cell suspension
|
small spleen
(
J:122463
)
|
• smaller spleen than that would be expected from the body size of the mice
|
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• smaller lymph nodes than that would be expected from the body size of the mice
|
neoplasm
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• no growth factor-independent colonies in cultured fetal livers and bone marrow cells transformed by Abelson oncogene or a murine stem-cell virus
• Abelson-transformed cells fail to induce leukemia in vivo
|
hematopoietic system
small thymus
(
J:122463
)
|
• smaller thymus than that would be expected from the body size and age of the mice
|
|
• B-cell development is arrested at the pre-pro-B-cell stage in survivor mice and in fetal liver-derived cultures
• no pro-B, immature, and mature B cells in cultures derived from fetal livers
• no early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively)
• reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively)
• few mature B-lymphoid cells are present in the periphery
|
|
• no early and late pro-B cells in the bone marrow (22-fold and 40-fold reduction, respectively)
• reduced numbers of mature B cells in spleen and lymph nodes(6.4-fold and 2.2-fold, respectively)
• few mature B-lymphoid cells are present in the periphery
|
|
• reduction of CD8+ T cells (2.5-fold) in the thymus
• reduction of CD8+ T cells (12-fold) in the lymph nodes
|
|
• absent CD4- CD8- gamma-delta TCR+ cells in the thymic cell suspension
|
small spleen
(
J:122463
)
|
• smaller spleen than that would be expected from the body size of the mice
|
endocrine/exocrine glands
small thymus
(
J:122463
)
|
• smaller thymus than that would be expected from the body size and age of the mice
|
