Phenotypes associated with this allele

• Allele Symbol: Ret^tm1Mat
• Allele Name: targeted mutation 1, Masahide Takahashi
• Allele ID: MGI:3055332
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1Mat/Ret^tm1Mat	involves: 129X1/SvJ * C57BL/6J	MGI:3055375

Genotype
MGI:3055375

hm1

• Allelic Composition: Ret^tm1Mat/Ret^tm1Mat
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92802 )

• homozygous mutants die by 27 days of age

digestive/alimentary system

abnormal colon morphology ( J:92802 )

• stenosis of the entire colon or dilation of the oral portion and stenosis of the anal portion of the colon is seen

abnormal small intestine morphology ( J:92802 )

• the small intestine is dilated

growth/size/body

kidney cyst ( J:92802 )

• cystic changes are seen in the tubules of some homozygotes

postnatal growth retardation ( J:92802 )

• mutants are the same size as wild-type at birth but display severe growth retardation by 13.5 days of age

distended abdomen ( J:92802 )

• a distended abdomen is seen by 10 days of age

renal/urinary system

kidney cyst ( J:92802 )

• cystic changes are seen in the tubules of some homozygotes

decreased kidney weight ( J:92802 )

• the ratio of kidney to body weight is about 50% that in wild-type mice

abnormal ureteric bud morphology ( J:92802 )

• the number of ureteric buds at E13,5 is significantly reduced in homozygotes compared to wild-type mice

nervous system

abnormal enteric nervous system morphology ( J:92802 )

• at E13.5 and E17.5 enteric nervous system progenitors are reduced or absent in the intestines of mutants

abnormal enteric ganglia morphology ( J:92802 )

• in the small intestine and colon ganglion cells are totally absent (40%) or reduced in number and size (60%) and the number of ganglion cells in the stomach is slightly reduced

• the number of neurons is not affected