All Phenotypes Myf5<tm2Tajb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf5^tm2Tajb
targeted mutation 2, Shahragim Tajbakhsh
MGI:3055343

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm2Tajb/Myf5^tm2Tajb	involves: 129S2/SvPas	MGI:3798775
hm2	Myf5^tm2Tajb/Myf5^tm2Tajb	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055419
ht3	Myf5^tm2Pas/Myf5^tm2Tajb	involves: 129S2/SvPas	MGI:3798776
cn4	Abl1^tm1Gcos/Abl1⁺ Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb Myod1^{tm2.1(icre)Glh}/Myod1⁺	involves: 129S * 129X1/SvJ * C57BL/6J	MGI:4939891
cx5	Myf5^tm2Tajb/Myf5^tm2Tajb Tbx1^tm1Pa/Tbx1^tm1Pa	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3850162
cx6	Myf5^tm2Tajb/Myf5⁺ Tbx1^tm1Pa/Tbx1^tm1Pa	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3850163
cx7	Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb	involves: 129S2/SvPas	MGI:3850158
cx8	Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6⁺	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3718095
cx9	Dmd^mdx-4Cv/Dmd^mdx-4Cv Myf5^tm2Tajb/Myf5^tm2Tajb	involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus	MGI:3798778
cx10	Myf5^tm2Tajb/Myf5^tm2Tajb Myod1^tm1Jae/Myod1^tm1Jae	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055420

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:168843 )

N	• genotoxins suppress skeletal myogenesis as in wild-type mice

abnormal skeletal muscle satellite cell proliferation ( J:128921 )

• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice

abnormal skeletal muscle morphology ( J:128921 )

increased skeletal muscle fiber diameter ( J:128921 )

• muscle fiber diameter is increased compared to wild-type mice

increased variability of skeletal muscle fiber size ( J:128921 )

• muscles contain fibers of varying diameters

centrally nucleated skeletal muscle fibers ( J:128921 )

• muscles contain fibers with centrally located nuclei

skeletal muscle fibrosis ( J:128921 )

• at 7 months of age mice, develop more fibrosis of the connective tissue than wild-type mice

• fibrosis of connective tissue following muscle injury is increased compared to in similarly treated wild-type mice

abnormal muscle regeneration ( J:128921 )

• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice

vision/eye

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:168843 )

N	• genotoxins suppress skeletal myogenesis as in wild-type mice

cellular

abnormal skeletal muscle satellite cell proliferation ( J:128921 )

• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

absent myotome ( J:92799 )

• at E10 early myotome is missing

abnormal skeletal muscle morphology ( J:92799 )

• dorsal muscles are absent

cellular

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

Allelic Composition	Myf5^tm2Pas/Myf5^tm2Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Pas mutation (0 available); any Myf5 mutation (17 available)
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle regeneration ( J:128921 )

• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice that is not as severe as in Myf5^tm2Tajb homozygotes

Allelic Composition	Abl1^tm1Gcos/Abl1⁺ Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb Myod1^{tm2.1(icre)Glh}/Myod1⁺
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1^tm1Gcos mutation (0 available); any Abl1 mutation (93 available)
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myf6^tm1Tajb mutation (0 available); any Myf6 mutation (19 available)
Myod1^{tm2.1(icre)Glh} mutation (1 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:168843 )

• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb Tbx1^tm1Pa/Tbx1^tm1Pa
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Tbx1^tm1Pa mutation (2 available); any Tbx1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal pharyngeal muscle morphology ( J:150130 )

• first-arch-derived muscles are absent in almost all mice

respiratory system

abnormal pharyngeal muscle morphology ( J:150130 )

• first-arch-derived muscles are absent in almost all mice

Allelic Composition	Myf5^tm2Tajb/Myf5⁺ Tbx1^tm1Pa/Tbx1^tm1Pa
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal pharyngeal muscle morphology ( J:150130 )

• mice exhibit sporadic asymmetric first-arch-derived muscles unlike in wild-type mice

respiratory system

abnormal pharyngeal muscle morphology ( J:150130 )

• mice exhibit sporadic asymmetric first-arch-derived muscles unlike in wild-type mice

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6^tm1Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myf6^tm1Tajb mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal extraocular muscle morphology ( J:150130 )

• mice phenocopy Myf5^tm1Pas homozygotes

abnormal eye muscle development ( J:150130 )

• mice phenocopy Myf5^tm1Pas homozygotes

vision/eye

abnormal extraocular muscle morphology ( J:150130 )

• mice phenocopy Myf5^tm1Pas homozygotes

abnormal eye muscle development ( J:150130 )

• mice phenocopy Myf5^tm1Pas homozygotes

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb Myf6^tm1Tajb/Myf6⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle development ( J:92799 )

• Myod expression is half that seen in wild-type mice

• before E10.5, markers of muscle differentiation are lacking

Allelic Composition	Dmd^mdx-4Cv/Dmd^mdx-4Cv Myf5^tm2Tajb/Myf5^tm2Tajb
Genetic Background	involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-4Cv mutation (3 available); any Dmd mutation (154 available)
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

increased skeletal muscle fiber diameter ( J:128921 )

• muscle fiber diameter is twice as large as in wild-type mice

skeletal muscle fiber necrosis ( J:128921 )

• the number of necrotic fibers and the size of necrotic foci is larger than in Dmd^mdx-4Cv homozygotes

Allelic Composition	Myf5^tm2Tajb/Myf5^tm2Tajb Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• only the double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth

absent skeletal muscle ( J:92799 )

• mutants essentially lack skeletal muscle throughout the body including the head

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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