Phenotypes associated with this allele

• Allele Symbol: Tg(CD8aCD8b)57Scr
• Allele Name: transgene insertion 57, The Scripps Research Institute
• Allele ID: MGI:3055355
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(B2M)55Hpl/? Tg(CD8aCD8b)57Scr/? Tg(HLA-B)22Hpl/?	involves: C57BL/6 * C57BL/LiA * CBA	MGI:3835121
tg2	Tg(CD8aCD8b)57Scr/?	B6;SJL-Tg(CD8aCD8b)57Scr/J	MGI:3835111

Genotype
MGI:3835121

cx1

• Allelic Composition: Tg(B2M)55Hpl/?; Tg(CD8aCD8b)57Scr/?; Tg(HLA-B)22Hpl/?
• Genetic Background: involves: C57BL/6 * C57BL/LiA * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytotoxic T cell physiology ( J:127813 )

• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27

• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M^-8) peptide concentrations

• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype

hematopoietic system

abnormal cytotoxic T cell physiology ( J:127813 )

• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27

• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M^-8) peptide concentrations

• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype

Genotype
MGI:3835111

tg2

• Allelic Composition: Tg(CD8aCD8b)57Scr/?
• Genetic Background: B6;SJL-Tg(CD8aCD8b)57Scr/J

immune system

abnormal effector T cell morphology ( J:92994 )

• 8-9% of splenocytes express human CD8alpha

• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers

• either CD4⁺ or CD8⁺ T cells can express the human CD8 complex in the periphery

abnormal cytotoxic T cell physiology ( J:92994 )

• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes

• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes

• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC

hematopoietic system

abnormal effector T cell morphology ( J:92994 )

• 8-9% of splenocytes express human CD8alpha

• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers

• either CD4⁺ or CD8⁺ T cells can express the human CD8 complex in the periphery

abnormal cytotoxic T cell physiology ( J:92994 )

• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes

• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes

• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC