Phenotypes associated with this allele

• Allele Symbol: Sh2b1^tm1Lr
• Allele Name: targeted mutation 1, Liangyou Rui
• Allele ID: MGI:3055487
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2b1^tm1Lr/Sh2b1^tm1Lr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3055518
ht2	Sh2b1^tm1Lr/Sh2b1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3055519

Genotype
MGI:3055518

hm1

• Allelic Composition: Sh2b1^tm1Lr/Sh2b1^tm1Lr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:92794 )

• islet size is increased but islets retain normal architecture

growth/size/body

decreased body size ( J:92794 )

• homozygotes are smaller during the first 5 weeks after birth

homeostasis/metabolism

hyperglycemia ( J:92794 )

• males develop hyperglycemia by 11 weeks of age with blood glucose levels about 1.5 fold higher compared to wild-type mice

impaired glucose tolerance ( J:92794 )

• 6 to 7 month old male mutants show intolerance to exogenous glucose

insulin resistance ( J:92794 )

• males develop progressive insulin resistance starting around 11 weeks of age

• females develop only mild insulin resistance

reproductive system

reduced fertility ( J:92794 )

• fertility is impaired

Genotype
MGI:3055519

ht2

• Allelic Composition: Sh2b1^tm1Lr/Sh2b1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

homeostasis/metabolism

hyperglycemia ( J:92794 )

• heterozygous males on a high fat diet more frequently develop hyperglycemia compared to wild-type mice