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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cldn11tm1Sts
targeted mutation 1, Shoichiro Tsukita
MGI:3055494
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cldn11tm1Sts/Cldn11tm1Sts involves: 129S4/SvJae * C57BL/6 MGI:3055550


Genotype
MGI:3055550
hm1
Allelic
Composition		 Cldn11tm1Sts/Cldn11tm1Sts
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cldn11tm1Sts mutation (0 available); any Cldn11 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal stria vascularis morphology ( J:92955 )
• the stria vascularis appears edematous
absent strial basal cell tight junctions ( J:92955 )
• the basal cell layer lacks tight junctions
decreased endocochlear potential ( J:92955 )
• generation of the endocochlear potential is impaired
• however, potassium concentration in the endolymph is normal
increased or absent threshold for auditory brainstem response ( J:92955 )
• 10 week old homozygous mutants have a sound pressure threshold of 40-60dB compared to 10-20 dB in wild-type mice

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory