Phenotypes associated with this allele

• Allele Symbol: Sstr1^tm1Dric
• Allele Name: targeted mutation 1, Dietmar Richter
• Allele ID: MGI:3055541
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sstr1^tm1Dric/Sstr1^tm1Dric	involves: 129S4/SvJae	MGI:3716347
hm2	Sstr1^tm1Dric/Sstr1^tm1Dric	involves: 129S4/SvJae * C57BL/6	MGI:3055594

Genotype
MGI:3716347

hm1

• Allelic Composition: Sstr1^tm1Dric/Sstr1^tm1Dric
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina apoptosis ( J:122896 )

• apoptotic cell death in retinas incubated in ischemic solution for 1hour is significantly lower than in wild-type retinas in the outer (35% vs 17%) and inner (21% vs 5%) nuclear layers of the retina and the granule cell layer (28% vs 9%)

• at 3 and 6 hours of incubation in ischemic solution, retinas of wild-type, Sstr1-null, and Sstr-2 null retinas show similar levels of apoptosis

nervous system

decreased synaptic glutamate release ( J:122896 )

• in ischemic retinas (ie. incubated in ischemic solution), rate of glutamate release is significantly reduced compared to wild-type retinas

cellular

abnormal retina apoptosis ( J:122896 )

• apoptotic cell death in retinas incubated in ischemic solution for 1hour is significantly lower than in wild-type retinas in the outer (35% vs 17%) and inner (21% vs 5%) nuclear layers of the retina and the granule cell layer (28% vs 9%)

• at 3 and 6 hours of incubation in ischemic solution, retinas of wild-type, Sstr1-null, and Sstr-2 null retinas show similar levels of apoptosis

Genotype
MGI:3055594

hm2

• Allelic Composition: Sstr1^tm1Dric/Sstr1^tm1Dric
• Genetic Background: involves: 129S4/SvJae * C57BL/6

vision/eye

abnormal retina rod bipolar cell morphology ( J:89799 )

• at postnatal day 14 and in adult mice, enlargements at the tips of the rod bipolar cells are 21+/-11% and 25+/-1% larger, respectively, than in wild-type mice

abnormal eye electrophysiology ( J:92978 )

• membrane capacitance of rod bipolar cells is increased and octreotide-induced inhibition of potassium current and glutamate release is enhanced in mutant retinas

nervous system

abnormal retina rod bipolar cell morphology ( J:89799 )

• at postnatal day 14 and in adult mice, enlargements at the tips of the rod bipolar cells are 21+/-11% and 25+/-1% larger, respectively, than in wild-type mice

abnormal brain wave pattern ( J:101285 )

• spontaneous bursting recorded in the hippocampal CA3 region is reduced 34% (18.0+/-0.2 per minute compared to 27.4+/-0.2 per minute in wild-type mice)

• unlike in wild-type mice, epileptiform activity is unaffected by SRIF, CH-275, SRA-880 and octreotide