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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd244atm1Kmle
targeted mutation 1, Kyung-Mi Lee
MGI:3055564
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd244atm1Kmle/Cd244atm1Kmle involves: C57BL/6 MGI:3055759


Genotype
MGI:3055759
hm1
Allelic
Composition		 Cd244atm1Kmle/Cd244atm1Kmle
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd244atm1Kmle mutation (0 available); any Cd244a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
increased natural killer cell mediated cytotoxicity ( J:92740 )
• mutant lymphokine-activated killer cells expressing CD244 are able to lyse target cells expressing CD48 unlike wild-type lymphokine-activated killer cells
• natural killer cell numbers and receptor repertoire are normal

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:166054 )
• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
increased natural killer cell mediated cytotoxicity ( J:92740 )
• mutant lymphokine-activated killer cells expressing CD244 are able to lyse target cells expressing CD48 unlike wild-type lymphokine-activated killer cells
• natural killer cell numbers and receptor repertoire are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory