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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		EnamRgsc521
RIKEN Genomic Sciences Center (GSC), 521
MGI:3055587
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		EnamRgsc521/EnamRgsc521 involves: C57BL/6JJcl * DBA/2J MGI:3574667
ht2
 		EnamRgsc521/Enam+ involves: C57BL/6JJcl * DBA/2J MGI:3574668


Genotype
MGI:3574667
hm1
Allelic
Composition		 EnamRgsc521/EnamRgsc521
Genetic
Background		 involves: C57BL/6JJcl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EnamRgsc521 mutation (1 available); any Enam mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
absent enamel ( J:96349 )
• enamel is absent from the incisors and molars

growth/size/body
absent enamel ( J:96349 )
• enamel is absent from the incisors and molars

skeleton
absent enamel ( J:96349 )
• enamel is absent from the incisors and molars

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta type 1B DOID:0110052 OMIM:104500
 J:96349




Genotype
MGI:3574668
ht2
Allelic
Composition		 EnamRgsc521/Enam+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EnamRgsc521 mutation (1 available); any Enam mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth morphology ( J:96349 )
• a gap is seen between the enamel and the dentin core
abnormal incisor morphology ( J:96349 )
• the incisor occlusion surface shows abnormal wear
abnormal enamel morphology ( J:96349 )
• the enamel surface appears slightly rougher and abnormal wear at the incisor occlusion surface suggests the enamel is softer, but enamel thickness is normal

growth/size/body
abnormal tooth morphology ( J:96349 )
• a gap is seen between the enamel and the dentin core
abnormal incisor morphology ( J:96349 )
• the incisor occlusion surface shows abnormal wear
abnormal enamel morphology ( J:96349 )
• the enamel surface appears slightly rougher and abnormal wear at the incisor occlusion surface suggests the enamel is softer, but enamel thickness is normal

skeleton
abnormal tooth morphology ( J:96349 )
• a gap is seen between the enamel and the dentin core
abnormal incisor morphology ( J:96349 )
• the incisor occlusion surface shows abnormal wear
abnormal enamel morphology ( J:96349 )
• the enamel surface appears slightly rougher and abnormal wear at the incisor occlusion surface suggests the enamel is softer, but enamel thickness is normal

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta type 1B DOID:0110052 OMIM:104500
 J:96349




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory