mortality/aging
• homozygotes died between E8.5 and E9.5
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Allele Symbol Allele Name Allele ID |
Brca2tm1Mhun targeted mutation 1, MC Hung MGI:3055613 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes died between E8.5 and E9.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• remain tumor free for over a year
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• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors
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• mammary tumor cell lines grew significantly faster after the third day in culture
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• very sensitive to DMBA induced apoptosis
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• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
breast cancer | DOID:1612 |
OMIM:114480 |
J:89083 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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