All Phenotypes Poli<d> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Poli^d
polymerase iota deficient
MGI:3055735

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Poli^d/Poli^d	B6.129-Poli^d	MGI:3691211
cx2	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli^d	B6.129-Polh^tm2Fmh Poli^d	MGI:3691209
cx3	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli⁺	B6.129-Polh^tm2Fmh Poli^d	MGI:3691210
cx4	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d	involves: 129P2/OlaHsd * C57BL/6	MGI:3579249
cx5	Poli^d/Poli^d Polk^tm1Hohm/Polk^tm1Hohm	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3623967

Allelic Composition	Poli^d/Poli^d
Genetic Background	B6.129-Poli^d

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Poli^d mutation (3 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:115000 )

N	• no difference in numbers of epithelial tumors induced by UV-B irradiation compared to wild-type mice

Allelic Composition	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli^d
Genetic Background	B6.129-Polh^tm2Fmh Poli^d

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm2Fmh mutation (0 available); any Polh mutation (38 available)
Poli^d mutation (3 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of induced tumors ( J:115000 )

• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli

• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice

• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli

Allelic Composition	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli⁺
Genetic Background	B6.129-Polh^tm2Fmh Poli^d

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of induced tumors ( J:115000 )

• tumors appear 4 weeks earlier than in mice wild-type for Poli

• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice

• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli

Allelic Composition	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm1Crey mutation (2 available); any Polh mutation (38 available)
Poli^d mutation (3 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

hematopoietic system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

Allelic Composition	Poli^d/Poli^d Polk^tm1Hohm/Polk^tm1Hohm
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Poli^d mutation (3 available); any Poli mutation (45 available)
Polk^tm1Hohm mutation (0 available); any Polk mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:105111 )

N	• exhibit normal immunoglobulin gene somatic hypermutation and normal B and T cell populations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24