All Phenotypes Btrc<tm1Paga> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btrc^tm1Paga/Btrc^tm1Paga	involves: 129S2/SvPas	MGI:3056062
cn2	Btrc^tm1Paga/Btrc^tm1Paga Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5568951
cn3	Btrc^tm1Paga/Btrc⁺ Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5568952

Allelic Composition	Btrc^tm1Paga/Btrc^tm1Paga
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrc^tm1Paga mutation (2 available); any Btrc mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:93010 )

• homozygous mice appeared generally as healthy as wildtype littermates over 2 years' observation

• almost all mutants revealed no gross tissue abnormalities upon necropsy

• exceptions were a single invasive intestinal carcinoma in a 10 month-old mouse and death due to thymic lymphoma of 2 mice aged 6.5 and 9 months

cellular

oligozoospermia ( J:93010 )

• histological examination of epidydimes of homozygous males revealed severely diminished numbers of mature spermatozoa

abnormal centrosome morphology ( J:93010 )

• approximately 20% of asynchronously dividing MEFs were found to have supernumerary centrosomes

abnormal male meiosis ( J:93010 )

• histological examination of epidydimes of homozygous males revealed evidence of prolonged, abnormal meiosis

• numbers of metaphase I spermatocytes were elevated

• in some mice, spindle abnormalities and misaligned chromosomes were observed

• the degree of fertility impairment correlated with the severity of histologic abnormality

abnormal meiotic spindle morphology ( J:93010 )

• in some spermatocytes, spindle abnormalities and misaligned chromosomes were observed

abnormal mitosis ( J:93010 )

• cultured homozygous mouse embryonic fibroblasts (MEFs) were retarded in their progression through mitosis, despite normal passage from G1 to S phase

• MEFs exhibited misalignment of chromosomes at the metaphase plate

• approximately 20% of asynchronously dividing MEFs were found to have supernumerary centrosomes, and approximately 12% of dividing MEFs exhibited multipolar spindles

abnormal mitotic spindle morphology ( J:93010 )

• approximately 12% of dividing MEFs exhibited multipolar spindles

reproductive system

oligozoospermia ( J:93010 )

• histological examination of epidydimes of homozygous males revealed severely diminished numbers of mature spermatozoa

abnormal male meiosis ( J:93010 )

• histological examination of epidydimes of homozygous males revealed evidence of prolonged, abnormal meiosis

• numbers of metaphase I spermatocytes were elevated

• in some mice, spindle abnormalities and misaligned chromosomes were observed

• the degree of fertility impairment correlated with the severity of histologic abnormality

abnormal meiotic spindle morphology ( J:93010 )

• in some spermatocytes, spindle abnormalities and misaligned chromosomes were observed

reduced male fertility ( J:93010 )

• approximately 50% of homozygous male mice produced no progeny when paired with wild-type females

• fertility defect was not behavioral in origin, as mating behavior was normal and vaginal plugs were observed

• productive homozygous males sired fewer and smaller litters, on average, than did wild-type males

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

rectal hemorrhage ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

diarrhea ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

abnormal enterocyte morphology ( J:206654 )

• wide gaps in epithelial tight junctions found in enterocytes following tamoxifen administration

abnormal intestinal mucosa morphology ( J:206654 )

• loss of most epithelial cells in large intestine following tamoxifen administration

• remaining mucosa is infiltrated with inflammatory and immune cells

• intestinal barrier disruption observed as early as 24 hours after tamoxifen treatment

abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )

• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration

abnormal colon morphology ( J:206654 )

• mice develop severe colitis following tamoxifen administration

• loss of most epithelial cells in large intestine following tamoxifen administration

• remaining mucosa is infiltrated with inflammatory and immune cells

intestinal inflammation ( J:206654 )

• inflammation in small and large intestines following tamoxifen administration

cellular

abnormal centrosome morphology ( J:206654 )

• more than 2 centrosomes observed in enterocytes following tamoxifen administration

abnormal mitosis ( J:206654 )

• mitosis is abnormally prolonged in enterocytes following tamoxifen administration

abnormal mitotic spindle morphology ( J:206654 )

• mitotic enterocytes have abnormal spindles following tamoxifen administration

chromosomal instability ( J:206654 )

• observed in enterocytes following tamoxifen administration

cardiovascular system

rectal hemorrhage ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )

• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:206654 )

• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

immune system

intestinal inflammation ( J:206654 )

• inflammation in small and large intestines following tamoxifen administration

increased circulating interleukin-1 beta level ( J:206654 )

• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

mortality/aging

premature death ( J:206654 )

• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

Allelic Composition	Btrc^tm1Paga/Btrc⁺ Fbxw11^tm1Ybn/Fbxw11^tm1Ybn Tg(Vil1-cre/ERT2)23Syr/?
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrc^tm1Paga mutation (2 available); any Btrc mutation (46 available)
Fbxw11^tm1Ybn mutation (0 available); any Fbxw11 mutation (72 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:206654 )

• severe inflammation and a disrupted epithelial layer occurs 4 days after tamoxifen administration

abnormal enterocyte morphology ( J:206654 )

• wide gaps in enterocyte epithelial tight junctions following tamoxifen administration

abnormal intestinal mucosa morphology ( J:206654 )

• mucositis observed in colon following tamoxifen administration

• spontaneous recovery occurs 3 weeks after tamoxifen administration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24