All Phenotypes rda MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

rda
roundabout
MGI:3055794

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	rda/rda	C57BL/6J-rda/JKjn	MGI:5437997
ht2	rda/rda⁺	C57BL/6J-rda/JKjn	MGI:6154680

Allelic Composition	rda/rda
Genetic Background	C57BL/6J-rda/JKjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
rda mutation (1 available); any rda mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cochlear hair cell abnormalities in rda/rda and Elmod1^rda-2J/Elmod1^rda-2J mice

hearing/vestibular/ear

abnormal inner hair cell stereociliary bundle morphology ( J:187273 )

• lengthened and fused at P15

fused inner hair cell stereocilia ( J:187273 )

• at P15

abnormal outer hair cell stereociliary bundle morphology ( J:187273 )

• in a few outer hair cells at P7 and P10

absent outer hair cell stereocilia ( J:187273 )

• in some cells at P15

decreased outer hair cell stereocilia number ( J:187273 )

• in a few outer hair cells at P7 and P10 adjacent to the kinocilium

• degeneration in all outer hair cells at P15

organ of Corti degeneration ( J:187273 )

• at 4 months

increased or absent threshold for auditory brainstem response ( J:187273 )

deafness ( J:187273 )

• profound by 5 weeks

behavior/neurological

absent startle reflex ( J:187273 )

circling ( J:187273 )

nervous system

abnormal inner hair cell stereociliary bundle morphology ( J:187273 )

• lengthened and fused at P15

fused inner hair cell stereocilia ( J:187273 )

• at P15

abnormal outer hair cell stereociliary bundle morphology ( J:187273 )

• in a few outer hair cells at P7 and P10

absent outer hair cell stereocilia ( J:187273 )

• in some cells at P15

decreased outer hair cell stereocilia number ( J:187273 )

• in a few outer hair cells at P7 and P10 adjacent to the kinocilium

• degeneration in all outer hair cells at P15

cochlear ganglion degeneration ( J:187273 )

• at 4 months

Allelic Composition	rda/rda⁺
Genetic Background	C57BL/6J-rda/JKjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
rda mutation (1 available); any rda mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:187273 )

N	• heterozygotes have normal hearing

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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