Analysis Tools
behavior/neurological
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• inability to swim
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head shaking
(
J:98396
)
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• shaking from side to side
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hearing/vestibular/ear
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• scanning electron microscopy analysis showed that inner and outer hair cells appear normal at birth
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• by P8, inner hair cells appear disorganized with loss of typical cell morphology
• by P50, the inner hair cells are severely splayed
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• by P8, outer hair cells appear disorganized with loss of typical cell morphology
• by P50, outer hair cells are absent, with empty patches appearing the basal portion of the cochlea
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• degeneration was more pronounced in the basal region than in the apex
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• ABR threshold testing showed that no mutant mouse tested exhibited a response to auditory stimuli up to 110 dB sound pressure level
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nervous system
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• scanning electron microscopy analysis showed that inner and outer hair cells appear normal at birth
|
|
• by P8, inner hair cells appear disorganized with loss of typical cell morphology
• by P50, the inner hair cells are severely splayed
|
|
• by P8, outer hair cells appear disorganized with loss of typical cell morphology
• by P50, outer hair cells are absent, with empty patches appearing the basal portion of the cochlea
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• described as decreased spiral ganglion
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