Phenotypes associated with this allele

• Allele Symbol: Mapk1^tm1Moga
• Allele Name: targeted mutation 1, Masato Ogata
• Allele ID: MGI:3055889
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk1^tm1Moga/Mapk1^tm1Moga	involves: 129P2/OlaHsd * C57BL/6	MGI:3055901

Genotype
MGI:3055901

hm1

• Allelic Composition: Mapk1^tm1Moga/Mapk1^tm1Moga
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89903 )

• most homozygotes die by E11.5; no embryos survive beyond E12.5

embryo

abnormal placental labyrinth vasculature morphology ( J:89903 )

• at E10.5, mutant placentas contain fetal blood vessels in the superficial layer; however, only a few fetal blood vessels penetrate into the labyrinthine layer

embryonic growth retardation ( J:89903 )

• at E10.5 and E11.5, most homozygotes show severe growth retardation and are significantly smaller than wild-type embryos, probably as a result of placental malfunction

thin placenta labyrinth ( J:89903 )

• at E10.5, homozygotes exhibit significantly thinner placental labyrinthine layers

abnormal placenta development ( J:89903 )

• at E10.5, homozygotes exhibit small placentas relative to wild-type embryos

growth/size/body

embryonic growth retardation ( J:89903 )

• at E10.5 and E11.5, most homozygotes show severe growth retardation and are significantly smaller than wild-type embryos, probably as a result of placental malfunction

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:89903 )

• at E10.5, mutant placentas contain fetal blood vessels in the superficial layer; however, only a few fetal blood vessels penetrate into the labyrinthine layer

thin myocardium ( J:89903 )

• at E10.5, homozygotes exhibit very thin heart walls relative to wild-type embryos

muscle

thin myocardium ( J:89903 )

• at E10.5, homozygotes exhibit very thin heart walls relative to wild-type embryos