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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk1tm2Moga
targeted mutation 2, Masato Ogata
MGI:3055890
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk1tm2Moga/Mapk1tm2Moga involves: 129P2/OlaHsd * C57BL/6 MGI:3055922
cn2
 		Mapk1tm2Moga/Mapk1tm2Moga
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Mx1-cre)1Cgn/? 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3797232


Genotype
MGI:3055922
hm1
Allelic
Composition		 Mapk1tm2Moga/Mapk1tm2Moga
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Moga mutation (0 available); any Mapk1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:89903 )
• phenotype is stated to be identical to that of Mapk1tm1Moga homozygotes; however no data are presented in J:89903

embryo

growth/size/body
embryonic growth retardation ( J:89903 )

cardiovascular system




Genotype
MGI:3797232
cn2
Allelic
Composition		 Mapk1tm2Moga/Mapk1tm2Moga
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Moga mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal pro-B cell morphology ( J:134528 )
• two weeks after Cre induction by pI-pC injection, the ratio of BP-1+HAShigh cells to BP-1+HASlow cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells
• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase
abnormal pro-B cell differentiation ( J:134528 )
• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice
• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice
decreased pre-B cell number ( J:134528 )
• two weeks after Cre induction by pI-pC injection, pre-B cell (B220lowIgM-Cd43-) numbers in the bone marrow are 7% of controls
• immature B cells (B220lowIgM+Cd43-) in the bone marrow are also reduced by a similar amount

hematopoietic system
abnormal pro-B cell morphology ( J:134528 )
• two weeks after Cre induction by pI-pC injection, the ratio of BP-1+HAShigh cells to BP-1+HASlow cells is much lower than in controls indicating a defect in the transition from pro-B cells to pre-B cells
• there is a 6-fold reduction in the percentage of pro B cells in the bone marrow that are in the S phase
abnormal pro-B cell differentiation ( J:134528 )
• bone marrow from mutant mice that have had induction of Cre by pI-pC injection are unable to reconstitute the B cell compartment in irradiated alymphoid mice
• reconstitution still fails when pro B cells are encouraged to differentiate by injection of Igbeta antibodies into the host mice
decreased pre-B cell number ( J:134528 )
• two weeks after Cre induction by pI-pC injection, pre-B cell (B220lowIgM-Cd43-) numbers in the bone marrow are 7% of controls
• immature B cells (B220lowIgM+Cd43-) in the bone marrow are also reduced by a similar amount




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory