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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fosl1tm2Wag
targeted mutation 2, Erwin F Wagner
MGI:3055991
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fosl1tm2Wag/Fosl1tm2Wag involves: 129P2/OlaHsd MGI:3056304
cn2
 		Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3056307


Genotype
MGI:3056304
hm1
Allelic
Composition		 Fosl1tm2Wag/Fosl1tm2Wag
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation (0 available); any Fosl1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:93053 )
• no overt abnormalities are seen




Genotype
MGI:3056307
cn2
Allelic
Composition		 Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation (0 available); any Fosl1 mutation (16 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoblast physiology ( J:93053 )
• deposition of mineralized extracellular matrix is strongly reduced
decreased bone mass ( J:93053 )
• progressive loss of bone mass
osteoporosis ( J:93053 )
• reduced bone mass is seen in the lumbar vertebral bodies and long bones and vertebral trabecular thickness is reduced in 6 week and 3 month old mutants

cardiovascular system
cardiovascular system phenotype ( J:95691 )
N
• transaortic constriction of the aorta (TAC) results in a comparable hypertrophic response as in controls

liver/biliary system
liver/biliary system phenotype ( J:213764 )
N
• in a model of liver fibrosis, mice exhibit a normal response

cellular
abnormal osteoblast physiology ( J:93053 )
• deposition of mineralized extracellular matrix is strongly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory