About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fosl1tm2Wag
targeted mutation 2, Erwin F Wagner
MGI:3055991
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fosl1tm2Wag/Fosl1tm2Wag involves: 129P2/OlaHsd MGI:3056304
cn2
 		Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3056307


Genotype
MGI:3056304
hm1
Allelic
Composition		 Fosl1tm2Wag/Fosl1tm2Wag
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation (0 available); any Fosl1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:93053 )
• no overt abnormalities are seen




Genotype
MGI:3056307
cn2
Allelic
Composition		 Fosl1tm2Wag/Fosl1tm2Wag
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl1tm2Wag mutation (0 available); any Fosl1 mutation (16 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoblast physiology ( J:93053 )
• deposition of mineralized extracellular matrix is strongly reduced
decreased bone mass ( J:93053 )
• progressive loss of bone mass
osteoporosis ( J:93053 )
• reduced bone mass is seen in the lumbar vertebral bodies and long bones and vertebral trabecular thickness is reduced in 6 week and 3 month old mutants

cardiovascular system
cardiovascular system phenotype ( J:95691 )
N
• transaortic constriction of the aorta (TAC) results in a comparable hypertrophic response as in controls

liver/biliary system
liver/biliary system phenotype ( J:213764 )
N
• in a model of liver fibrosis, mice exhibit a normal response

cellular
abnormal osteoblast physiology ( J:93053 )
• deposition of mineralized extracellular matrix is strongly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory