Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hdac5tm1Eno targeted mutation 1, Eric N Olson MGI:3056065 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by 8 months of age mutant hearts are 20% larger than wild-type due to hypertrophy
• the hypertrophic response induced by increased afterload is increased in mutants compared to wild-type mice
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• by 8 months of age mutant hearts are 20% larger than wild-type due to hypertrophy
• the hypertrophic response induced by increased afterload is increased in mutants compared to wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• soleus muscles show an increase in the percentage of slow myofibers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 1 mouse is present at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit reduced kidney cyst formation compared with Pkd2tm2Som homozygotes
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• mice exhibit reduced kidney cyst formation compared with Pkd2tm2Som homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygous embryos begin to die around E15.5 with only about 12% of double homozygotes surviving to adulthood
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• at E15.5 ventricular septal defects were seen in 77% of double homozygous embryos often associated with hemorrhages
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• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated
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• at E15.5 thin ventricular walls were seen in 20% of double homozygous embryos often associated with hemorrhages
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• hemorrhages are seen throughout the body of some mutant embryos at E15.5
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• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated
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• severe growth retardation is seen with surviving adults weighing 1/3 as much as wild-type mice
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• soleus muscles show an increase in the percentage of slow myofibers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice
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• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transgenic mice are highly susceptible to sudden death from heart failure with none surviving beyond 8 weeks of age
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• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy
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• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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