Phenotypes associated with this allele

• Allele Symbol: Trp53^tm4Tyj
• Allele Name: targeted mutation 4, Tyler Jacks
• Allele ID: MGI:3056071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm4Tyj/Trp53^tm4Tyj	involves: 129S4/SvJae * C57BL/6	MGI:3056328

Genotype
MGI:3056328

hm1

• Allelic Composition: Trp53^tm4Tyj/Trp53^tm4Tyj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92917 )

• median survival time (444 days) is reduced compared to wild-type but increased compared to Trp53 null homozygotes

neoplasm

increased B cell derived lymphoma incidence ( J:92917 )

• a variety of B-cell derived tumors are seen in 62% of mutants including follicular, diffuse large cell, and marginal zone as well as plasmacytomas

increased sarcoma incidence ( J:92917 )

• 3 mutants had sarcomas including 2 with hstiocytic sarcoma and 1 with hemangiosarcoma

• in addition single cases of lung adenoma, lung adenocarcinoma, hepatoma, and hair matrix tumor were seen

cellular

decreased cellular sensitivity to gamma-irradiation ( J:92917 )

• resistance to ionizing radiation-induced apoptosis of cultured thymocytes and in vivo splenic B-cells and the external granule layer of the developing cerebellum is seen