Phenotypes associated with this allele

• Allele Symbol: Ndufa13^tm1Xc
• Allele Name: targeted mutation 1, Xinmin Cao
• Allele ID: MGI:3056073
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndufa13^tm1Xc/Ndufa13^tm1Xc	either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6)	MGI:3056150

Genotype
MGI:3056150

hm1

• Allelic Composition: Ndufa13^tm1Xc/Ndufa13^tm1Xc
• Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:93022 )

• mutant embryos die before E9.5

cellular

abnormal mitochondrial crista morphology ( J:93022 )

• after 3 days in culture mitochondria in blastocyst cells have poorly developed cristae

abnormal mitochondrial shape ( J:93022 )

• after 3 days in culture mitochondria in blastocyst cells are round and distended

embryo

failure to gastrulate ( J:93022 )

• no gastrulation is seen at E7.5 and only a partial gastrulation that does not develop further can be seen at E8.5

• also at E8.5 no organogenesis can be seen

decreased embryo size ( J:93022 )

• at E5.5 mutants are smaller and disorganized compared to wild-type embryos

abnormal inner cell mass morphology ( J:93022 )

• at E3.5 the inner cellular is smaller and its outgrowth is retarded

• the boundary between the inner cellular mass and the trophoblast is indistinct

abnormal trophectoderm morphology ( J:93022 )

• at E3.5 the trophoblast is smaller and no giant cells are detected

• the boundary between the inner cellular mass and the trophoblast is indistinct

growth/size/body

decreased embryo size ( J:93022 )

• at E5.5 mutants are smaller and disorganized compared to wild-type embryos