Phenotypes associated with this allele

• Allele Symbol: Ctnnb1^tm1Yy
• Allele Name: targeted mutation 1, Yingzi Yang
• Allele ID: MGI:3056113
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm1Yy/Ctnnb1^tm1Yy Twist2^tm1(cre)Dor/Twist2^+	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3056292
cn2	Ctnnb1^tm1Yy/Ctnnb1^tm1Yy Tg(Col2a1-cre)1Bhr/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3056288
cn3	Ctnnb1^tm1Yy/Ctnnb1^tm1Yy Tg(Prnp-GFP/cre)1Blw/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3056291
cn4	Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy Ptch1^tm1Yy/Ptch1^tm1.1Yy Tg(Col2a1-cre)1Bhr/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3687747
cn5	Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy Tg(Col2a1-cre)1Bhr/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3687748
cn6	Ctnnb1^tm1Yy/Ctnnb1^tm1Yy Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6J * SJL/J	MGI:5426940

Genotype
MGI:3056292

cn1

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1Yy; Twist2^tm1(cre)Dor/Twist2⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

fused synovial joints ( J:93028 )

• fused joints are seen in the elbow, hip, knee, ankle, and digit regions

Genotype
MGI:3056288

cn2

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1Yy; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:93028 )

• mutants die shortly after birth

craniofacial

domed cranium ( J:93028 )

limbs/digits/tail

short limbs ( J:93028 )

skeleton

domed cranium ( J:93028 )

fused synovial joints ( J:93028 )

• the calcaneus is fused to the cuboid and the navicular is partially fused to the intermediate cuneiforms at E15.5

Genotype
MGI:3056291

cn3

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1Yy; Tg(Prnp-GFP/cre)1Blw/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:93028 )

• mutants die shortly after birth

craniofacial

domed cranium ( J:93028 )

limbs/digits/tail

short limbs ( J:93028 )

skeleton

domed cranium ( J:93028 )

fused synovial joints ( J:93028 )

• the calcaneus is fused to the cuboid and the navicular is partially fused to the intermediate cuneiforms at E15.5

Genotype
MGI:3687747

cn4

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy; Ptch1^tm1Yy/Ptch1^tm1.1Yy; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

cellular

arrested osteoblast differentiation ( J:112462 )

• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

skeleton

arrested osteoblast differentiation ( J:112462 )

• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

abnormal elbow joint morphology ( J:112462 )

• the elbow joint interzone fails to form

abnormal long bone hypertrophic chondrocyte zone ( J:112462 )

• chondrocyte hypertrophy is inhibited

fused synovial joints ( J:112462 )

• show extensive synovial joint fusions which are much more severe than in each of the single mutants

abnormal perichondrium morphology ( J:112462 )

• perichondrium is thinner

decreased bone mineralization ( J:112462 )

• mineralization in the long bones is more severely reduced than in single conditional Ctnnb1 mutants

delayed endochondral bone ossification ( J:112462 )

• ossification is more severely inhibited than in single conditional Ctnnb1 mutants

craniofacial

craniofacial phenotype ( J:112462 )

N • exhibit normal posterior skull formation

limbs/digits/tail

abnormal elbow joint morphology ( J:112462 )

• the elbow joint interzone fails to form

Genotype
MGI:3687748

cn5

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1.1Yy; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

cellular

increased chondrocyte apoptosis ( J:112462 )

• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

skeleton

increased chondrocyte apoptosis ( J:112462 )

• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

abnormal perichondrium morphology ( J:112462 )

• perichondrium is thinner

decreased bone mineralization ( J:112462 )

• mineralization is decreased

failure of bone ossification ( J:112462 )

• ossification is inhibited

Genotype
MGI:5426940

cn6

• Allelic Composition: Ctnnb1^tm1Yy/Ctnnb1^tm1Yy; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

limbs/digits/tail

abnormal limb development ( J:184918 )

• authors state that mice exhibit the same defects as in Wls^tm1Xzg/Wls^tm1Xzg Tg(Msx2-cre)5Rem mice

integument

abnormal hair follicle development ( J:184918 )

• loss of hair follicles in the dorsal dermis of the limb

muscle

abnormal tendon morphology ( J:184918 )

• in the forelimbs at E17.5

skeleton

abnormal tendon morphology ( J:184918 )

• in the forelimbs at E17.5

abnormal ligament morphology ( J:184918 )

• in the forelimbs at E17.5

pigmentation

abnormal melanogenesis ( J:184918 )

• loss of melanogenesis in the dorsal dermis of the limb