All Phenotypes Adgrg2<tm1Bend> MGI Mouse

asthenozoospermia ( J:93019 )

• the proportion of motile sperm as well as the absolute motility of sperm is reduced

dilated seminiferous tubule ( J:93019 )

• the seminiferous tubules are dilated as a result of fluid accumulation

enlarged testis ( J:93019 )

• enlarged testes are seen by 2 months of age as a result of fluid accumulation

abnormal spermatogenesis ( J:93019 )

• reduced spermatogenesis is seen as a result of reduced differentiation in the germ layer epithelia however all stages of spermatogenesis are present

oligozoospermia ( J:93019 )

• at 12 weeks of age, the number of cauda spermatozoa is drastically reduced

teratozoospermia ( J:93019 )

• most of the sperm present show frequent morphological abnormalities

kinked sperm flagellum ( J:93019 )

• many sperm show a sharp bend in the flagellum

absent sperm head ( J:93019 )

• an increased number of acephalic spermatozoa is observed

dilated efferent ductule of testis ( J:93019 )

• the ductules are dilated and often obstructed with accumulated spermatozoa

abnormal cauda epididymis morphology ( J:93019 )

• clear-cell activity is increased in the cauda region

• however, the caput epididymis, including the most proximal region ("initial segment") appears morphologically normal

small epididymis ( J:93019 )

• the epididymis is reduced in size

decreased epididymis weight ( J:93019 )

• the epididymis is reduced in weight

reduced male fertility ( J:93019 )

• a progressive and severe reduction in male fertility is seen resulting in almost complete infertility by 15 weeks of age