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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dand5tm1Belo
targeted mutation 1, Jose Antonio Belo
MGI:3056132
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dand5tm1Belo/Dand5tm1Belo either: (involves: 129P/Ola) or (involves: 129P/Ola * C57BL/6J) MGI:3056265
cx2
 		Dand5tm1Belo/Dand5tm1Belo
Nodaltm1.1Mku/Nodal+ 		involves: 129/Ola * C57BL/6J MGI:3056267


Genotype
MGI:3056265
hm1
Allelic
Composition		 Dand5tm1Belo/Dand5tm1Belo
Genetic
Background		 either: (involves: 129P/Ola) or (involves: 129P/Ola * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dand5tm1Belo mutation (0 available); any Dand5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:93051 )
• 25% of mutants die between weaning and 3 months of age
neonatal lethality, incomplete penetrance ( J:93051 )
• 35% of homozygotes die with 48 hours after birth

cardiovascular system
abnormal direction of heart looping ( J:93051 )
• 54% of mutant embryos display leftward or ventral heart looping
atrial septal defect ( J:93051 )
• 64% of neonates that die display incomplete atrial septation
ventricular septal defect ( J:93051 )
• 64% of neonates that die display incomplete ventricular septation

embryo
abnormal left-right axis patterning ( J:93051 )
• a number of markers of left-right morphogenesis are abnormally expressed

growth/size/body
left pulmonary isomerism ( J:93051 )
• 18% of neonates that die have left pulmonary isomerism
situs inversus ( J:93051 )
• 18% of neonates that die show thoracic situs inversus
• mutants that die between weaning and 3 months of age display reversal of many of the abdominal organs

respiratory system
left pulmonary isomerism ( J:93051 )
• 18% of neonates that die have left pulmonary isomerism




Genotype
MGI:3056267
cx2
Allelic
Composition		 Dand5tm1Belo/Dand5tm1Belo
Nodaltm1.1Mku/Nodal+
Genetic
Background		 involves: 129/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dand5tm1Belo mutation (0 available); any Dand5 mutation (16 available)
Nodaltm1.1Mku mutation (0 available); any Nodal mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal direction of heart looping ( J:93051 )
• 35% of compound mutant embryos display leftward or ventral heart looping




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory